Clinical trials: in Pakistan
Melasma
COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA
Melasma is a common acquired hyperpigmentation disorder that significantly affects quality of life. Various topical agents are used in its treatment, including Vitamin C and Niacinamide, both of which possess depigmenting…
- Trial name
- NCT07890571
- Testing
- Ascorbic acid, niacinamide
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Pak Emirates Military Hospital
Stroke
Comparison of Exergaming Training With Visual Feedback Training on Upper Limb Functions in Post Stroke Patients
Stroke is classically characterized as a neurological deficit attributed to an acute focal injury of the central nervous system (CNS) by a vascular cause, including transient ischemic attack, cerebral infarction, intracerebral…
- Trial name
- NCT05673421
- Testing
- Exergaming Training, Visual Feedback Training
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Cerebral Venous Sinus Thrombosis
MENA Regional Endovascular Intervention for Venous Cerebral Venous Sinus Thrombosis
REVIVE-CVST is a multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) trial evaluating whether early endovascular thrombectomy (EVT) combined with standard anticoagulation improves outcomes compared to…
- Trial name
- REVIVE-CVST (NCT07548346)
- Testing
- Endovascular Thrombectomy, Anticoagulation Therapy
- Where
- 14 sites in Egypt, Jordan and 6 more
- Volunteers
- 440 people
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Cervical Spondylitis
Reciprocal Inhibition vs PNF for Cervical Spondylitis
Cervical spondylitis is a common cause of chronic neck pain and limited function. Physiotherapists often use two manual techniques: Reciprocal Inhibition (RI) and Passive Proprioceptive Neuromuscular Facilitation (PNF)…
- Trial name
- RI-PNF-CS (NCT07637812)
- Testing
- Reciprocal Inhibition Technique, Passive PNF Stretching
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Faisalabad
Beta-Thalassemia, Thalassemia
Combination Therapy With Danazol, Prednisolone, and Thalidomide for Thalidomide-Refractory Transfusion-Dependent β-Thalassemia
This study will compare two treatments for children with beta-thalassemia who need regular blood transfusions and have not responded well to thalidomide. One group will continue thalidomide alone.
- Trial name
- NCT07884773
- Testing
- Thalidomide, Danazol, Prednisolone
- Where
- Pakistan
- Volunteers
- 172 people
- Sponsor
- Khyber Medical University Peshawar
Chronic Anal Fissure
Topical Nitroglycerin Versus Lateral Internal Sphincterotomy for Chronic Anal Fissure
Chronic anal fissure is a tear in the lining of the anal canal that can cause pain during and after defecation. This randomized controlled trial will compare topical 0.2% nitroglycerin ointment with lateral internal…
- Trial name
- NCT07884916
- Testing
- Topical 0.2% Glyceryl Trinitrate (Nitroglycerin) Ointment, Lateral Internal Sphincterotomy
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Pituitary Adenoma
Comparison of Extent of Resection of Pituitary Adenoma Via Transnasal Transsphenoidal Approach Using Endoscope Versus Microscope
This randomized controlled trial, titled "Comparison of Extent of Resection of Pituitary Adenoma via Transnasal Transsphenoidal Approach Using Endoscope Versus Microscope," was conducted in the Department of Neurosurgery, Sir…
- Trial name
- GTR MRI (NCT07886242)
- Testing
- Endoscopic surgery, Microscopic surgery
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Sir Ganga Ram Hospital
Stroke
Effectiveness of Epley Maneuver Versus Semont Maneuver on Dizziness and Balance in Stroke Survivors With Posterior Canal BPPV
This randomized controlled trial aims to compare the effectiveness of the Epley maneuver and the Semont maneuver in reducing dizziness and improving balance in stroke survivors diagnosed with posterior canal benign paroxysmal…
- Trial name
- NCT07887191
- Testing
- Epley Maneuver, Semont Maneuver
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Ibadat International University, Islamabad
Stroke
Effect of Lower Limb Proprioceptive Neuromuscular Facilitation Combined With Core Stability Training Versus Proprioceptive Neuromuscular Facilitation Alone on Balance and Functional Mobility in Chronic Stroke Survivors
This randomized controlled trial compares lower limb proprioceptive neuromuscular facilitation (PNF) combined with core stability training versus lower limb PNF alone in chronic stroke survivors.
- Trial name
- NCT07887360
- Testing
- Lower Limb PNF Combined with Core Stability Training, Lower Limb PNF alone
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Ibadat International University, Islamabad
Lumbar Radiculopathy
Comparative Effect Between Mulligan Leg Raise and Spinal Mobilization With Limb Movement in Lumbar Radiculopathy
This study examines the comparative effects of mulligan leg raise traction and Spinal Mobilization with Leg Movement (SMWLM) on lumbar radiculopathy
- Trial name
- NCT07887685
- Testing
- Mulligan Leg Raise traction, Spinal Mobilization with Limb Movement - SMWLM
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Foundation University Islamabad
Cerival Pain, Chronic Neck Pain
Effects of Instrument-Assisted Soft Tissue Mobilization Versus Post Facilitation Stretch Technique in Chronic Neck Pain
Chronic neck pain is a prevalent musculoskeletal condition that commonly results in persistent pain, reduced cervical range of motion (ROM), functional disability, and decreased quality of life.
- Trial name
- NCT07887698
- Testing
- Instrument Assisted Soft Tissue Mobilization, Post Facilitation Stretch
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Foundation University Islamabad
Suicide, Suicide Prevention
Suicide Prevention Integration Into Task-shifted Mental Health Interventions
Investigators will conduct a pilot clinical trial to assess the feasibility and acceptability of implementing a Suicide Prevention Package (SuPP) within an existing task-shifted depression intervention in rural Pakistan.
- Conditions
- Suicide, Suicide Prevention, Suicidal Ideation
- Trial name
- KPZ (NCT06208293)
- Testing
- KPZ Program (KPZ), Enhanced Usual Care (EUC)
- Where
- Pakistan
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Yale University
Type 2 Diabetes Mellitus, Hypercholesterolemia / Elevated LDL Cholesterol
Dual vs Triple Lipid-Lowering Therapy in Type 2 Diabetes Mellitus Patients With Elevated LDL Cholesterol
This Open-label, randomized clinical trial evaluates the comparative efficacy and safety of dual versus triple lipid-lowering therapy using rosuvastatin, ezetimibe, and bempedoic acid in patients with type 2 diabetes mellitus and…
- Trial name
- NCT07255820
- Testing
- Rosuvastatin + Ezetimibe, Bempedoic Acid + Ezetimibe, Rosuvastatin + Ezetimibe + Bempedoic Acid
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Bahria University
Symptomatic Irreversible Pulpitis (SIP)
Short Term Comparative Assessment of MTA and Biodentine in Complete Pulpotomy for Symptomatic Irreversible Pulpitis
All Patients coming to the Operative Dentistry Department (DIDC-DUHS) with complain of pain in posterior teeth will be invited to participate. The treatment will be done by one dentist.
- Trial name
- NCT07483788
- Testing
- Biodentine pulpotomy
- Where
- 2 sites in Pakistan
- Volunteers
- 60 people
- Sponsor
- Dow University of Health Sciences
Prediabetes or Overweight, Obesity Type 2 Diabetes Mellitus
Real-World Outcomes of Tirzepatide in Pakistani Adults With Obesity, Prediabetes, and Type 2 Diabetes
This is a multicentre, prospective, observational study of the medicine tirzepatide as it is used in routine clinical care in Pakistan.
- Conditions
- Prediabetes or Overweight, Obesity Type 2 Diabetes Mellitus, Obesity & Overweight
- Trial name
- TRIBUTE-PK (NCT07809568)
- Where
- 9 sites in Pakistan
- Volunteers
- 330 people
- Sponsor
- Universiti Sains Malaysia
Intertrochanteric Femoral Fracture
DHS Fixation for Extra Capsular Fractures of Proximal Femur in Geriatric Population
This study compares two approaches to starting walking and weight bearing after surgery for a fracture near the hip in older adults.
- Trial name
- NCT07874477
- Testing
- Early weight bearing, Delayed mobilization
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Hayat Abad Medical Complex, Peshawar
Pes Anserine Bursitis
Comparison of Bracing and Eccentric Loading Exercises on Pain Modulation and Functional Improvement in Acute Pes Anserine Bursitis Patients
This study aims to compare the effects of knee bracing and eccentric loading exercises on pain and functional ability in adults with acute pes anserine bursitis.
- Trial name
- NCT07881913
- Testing
- Medial-Support Knee Brace, Eccentric Loading Exercise
- Where
- 2 sites in Pakistan
- Volunteers
- 32 people
- Sponsor
- Dr Aneeqa Sultan
Treatment
Evaluating the Effectiveness of an Adapted-Dialectical Behavior Therapy (A-DBT)
Adapted-Dialectical Behavioral Therapy (A-DBT) Adolescence Manual (Urdu version) An A-DBT Adolescence Urdu version Manual was used consisted of techniques related to mindfulness, emotion regulation, interpersonal effectiveness…
- Trial name
- A-DBT (NCT07883408)
- Testing
- Adapted Dialectical Behavioral Therapy (A-DBT)
- Where
- Pakistan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- International Islamic University, Islamabad
Episiotomy , Perineal Pain
Pudendal Nerve Block for Pain Relief During Episiotomy Repair: A Randomized Controlled Trial
Episiotomy is a surgical cut made in the perineum, the area between the vagina and anus, during vaginal childbirth. Repairing an episiotomy can cause pain, and adequate pain relief is important for maternal comfort during and…
- Trial name
- NCT07883473
- Testing
- Pudendal Nerve Block, Conventional Local Perineal Infiltration
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Chronic Non-Specific Low Back Pain
Dynamic Versus Traditional Core Strengthening Exercises in Patients With Chronic Non-specific Low Back Pain
This research investigated the effectiveness of two different types of core strengthening exercises: dynamic versus traditional exercises.
- Trial name
- CNLBP (NCT07884396)
- Testing
- Routine Physiotherapy, Dynamic Core Strengthening Exercises, Traditional Core Strengthening Exercises
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- University of Lahore
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