Clinical trials: Simvastatin
Bone Injury
Salivary Bmp-2 Levels & Radiographic Measurement Of Bone Density at Extracted Tooth
Salivary Bmp-2 Levels \& Radiographic Measurement Of Bone Density were evaluated At Extracted Tooth Socket in patients With \& Without topical Application Of Simvastatin
- Trial name
- salivaryBMP2 (NCT05369091)
- Testing
- Simvastatin 10mg
- Where
- Pakistan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Postgraduate Medical Institute, Lahore
Three Wall Intrabony Defects in Chronic Periodontitis
Platelet Rich Fibrin Combined With Simvastatin for Treatment of Intrabony Defect in Chronic Periodontitis
The purpose of the present study was to investigate the efficacy of autologous Platelet rich fibrin (PRF) or PRF and Simvastatin (SMV) with open flap debridement (OFD) in the treatment of three wall intrabony defects in…
- Trial name
- NCT02120872
- Testing
- Platelet rich fibrin and simvastatin, Platelet rich fibrin, Open Flap Debridement alone
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Cystic Fibrosis
Pilot Mouthwash Study of Pioglitazone and Simvastatin in Healthy Volunteers
Inflammation clearly contributes to the progression of the cystic fibrosis (CF) lung disease, and administration of the anti-inflammatory agent high-dose ibuprofen retards the rate of decline of pulmonary function.
- Trial name
- NCT00531882
- Testing
- Pioglitazone, Simvastatin, Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Healthy Volunteer
Bioequivalence Study of Simvastatin 40 mg Film-coated Tablets in Healthy Thai Volunteers
The goal of this bioequivalence study is to determine and compare the rate and extent of absorption and to evaluate safety of test and reference formulations.
- Trial name
- NCT06178640
- Testing
- Simvastatin 40 mg film-coated tablet, Zocor 40 mg film-coated tablet
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- International Bio service
Type 2 Diabetes
The DDI Study of SP2086 and Simvastatin
The purpose of the study is to investigate the potential interaction between multiple oral doses of SP2086 and a single oral dose of Simvastatin in healthy adult volunteers.
- Trial name
- NCT02817243
- Testing
- SP2086, Simvastatin
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Diabetes Mellitus, Type 2
A Study to Investigate the Interaction of GSK1292263 With Rosuvastatin and Simvastatin in Healthy Subjects
This study is a Phase I, open-label, single-sequence drug interaction study to evaluate the effect of repeated doses of GSK1292263 on the pharmacokinetics of rosuvastatin and simvastatin in healthy adult subjects.
- Trial name
- NCT01101568
- Testing
- Simvastatin, Rosuvastatin, GSK1292263
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Simvastatin, Photodynamic Therapy
Treatment of Intrabony Defects With Simvastatin and Antimicrobial Photodynamic Therapy
Antimicrobial photodynamic therapy (aPDT) is characterized by the association of photosensitizing agents, promoting the generation of reactive oxygen species like free radicals and singlet oxygen, which are cytotoxic to certain…
- Conditions
- Simvastatin, Photodynamic Therapy, Periodontal Diseases
- Trial name
- NCT05031923
- Testing
- SMV and antimicrobial photodynamic therapy, SMV application
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Healthy Volunteers
A Study to Assess Co-Administered AZD9056 (Steady State) and Simvastatin (Single Dose) in Healthy Volunteers
The purpose of the study is to assess the pharmacokinetics of both AZD9056 (steady state) and simvastatin (single dose) when co-administered in healthy volunteers
- Trial name
- NCT00736606
- Testing
- simvastatin, AZD9056 + simvastatin
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Subjects
A Study to Evaluate the DDI of DBPR108 With Metformin,Glibenclamide,Valsartan, or Simvastatin in Healthy Subjects
This is a four-part, single-center, open-label, single-sequence crossover phase I clinical study to characterize the Drug-Drug Interaction (DDI) potential of DBPR108 at steady-state with Metformin hydrochloride, Glibenclamide…
- Trial name
- NCT04859452
- Testing
- DBPR108 tablets, Metformin hydrochloride tablets, Glibenclamide tablets
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Hypercholesterolemia, Chronic Kidney Diseases
Lipid-lowering Therapies in Vietnamese Chronic Kidney Disease Population
This study aims to determine the mechanisms underlying dyslipidemia in chronic kidney disease (CKD) and effect of lipid-lowering therapies in patients with CKD via parameters of lipid, oxidative stress, tryptophan delegation as…
- Trial name
- VietCKD (NCT03543774)
- Testing
- Simvastatin 40mg, Ezetimibe/simvastatin 10/20 mg/day, Ezetimibe/simvastatin 10/40 mg/day
- Where
- Vietnam
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hue University of Medicine and Pharmacy
Depression, Inflammation
7-day Simvastatin and Emotional Processing
Work in our group has revealed that short-term (7-day) administration of antidepressants produces positive biases in the processing of emotional information in healthy volunteers.
- Trial name
- SSTEP-HV (NCT04652089)
- Testing
- Simvastatin 20mg
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Dyslipidemias
Effects of Statin Medications on Mental Processes, Behavior, and Serotonin Levels
Statins are cholesterol-lowering medications that are often prescribed for individuals with high cholesterol and who are at risk for heart disease.
- Trial name
- NCT00330980
- Testing
- 40 mg Pravastatin (Pravachol), 20 mg Simvastatin
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Hyperglycemia
Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
Anesthetic preconditioning (APC, a brief exposure to an anesthetic gas) has become an area of intense research interest because of its ability to protect tissue and organs from injury resulting from a cessation of blood flow and…
- Trial name
- NCT00995670
- Testing
- 5% dextrose, Vitamin C, Simvastatin
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Healthy
Pharmacokinetics of Simvastatin and Its Metabolite Simvastatin Acid With and Without Concomitant Administration of Telmisartan in Healthy Subjects
To assess the pharmacokinetics of simvastatin and simvastatin acid with/without concomitant administration of telmisartan
- Trial name
- NCT02187536
- Testing
- Telmisartan, Simvastatin
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
Drug Interaction Study of MGL-3196 With Rosuvastatin and Simvastatin
The purpose of this study is to determine whether MGL-3196 alters the pharmacokinetics of rosuvastatin and/or simvastatin in healthy male subjects and female subjects not of child-bearing potential.
- Trial name
- NCT02542969
- Testing
- Simvastatin, Rosuvastatin, MGL-3196
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Madrigal Pharmaceuticals, Inc.
Alzheimer's Disease
Effects of Simvastatin on Biomarkers
A year-long randomized, double-blind, placebo-controlled trial of simvastatin to see if it produces beneficial changes in cerebral spinal fluid proteins associated with Alzheimer's disease.
- Trial name
- SimBio (NCT01142336)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cholesterol, LDL
Comparison of Efficacy and Safety of Ezetimibe or Statin Monotherapy to Co-Administration of Both
The purpose of this study is to compare the percent change in LDL cholesterol induced by ezetimibe or simvastatin monotherapy and by co-administration of both agents in Black, White and Hispanic men.
- Trial name
- NCT00461968
- Testing
- Ezetimibe and Simvastatin
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Pulp Disease, Dental, Deciduous Teeth
3Mixtatin and MTA Vital Pulpotomy in Primary Molars
The aim of the study is to evaluate clinical and radiographic success of using 3Mixtain versus mineral trioxide aggregate in pulpotomy of deeply carious Primary molars.
- Trial name
- NCT06478940
- Testing
- 3 mixtatin pulpotomy, MTA pulpotomy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Alzheimer's Disease
GSK2647544 RD, DDI in Healthy Young and Elderly Volunteers
GSK2647544 is an orally available, selective inhibitor of Lp PLA2 that is being developed for the treatment of Alzheimer's disease.
- Trial name
- NCT01978327
- Testing
- GSK2647544, drug-drug interaction
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes Mellitus
A Study To Estimate The Effect Of Repeated Dosing of PF-05175157 On The Pharmacokinetics Of A Single Dose Of Simvastatin In Healthy Adult Subjects
The study is designed to investigate the effect of repeated dosing of PF-05175157 on the pharmacokinetics of a single dose of Simvastatin in healthy adult subjects.
- Trial name
- NCT01469468
- Testing
- Simvastatin, PF-05175157
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Pfizer