Clinical trials: sponsored by Charles University, Czech Republic
Trauma, Brain
Risk Assessment of Mild Traumatic Brain Injury in Military Training
The SNIPER-TBI study aims to identify and quantify the risk of mild traumatic brain injury (mTBI) in soldiers of the Czech Armed Forces during specific high-risk training activities, including parachute jumps, high-caliber…
- Trial name
- NCT06992570
- Testing
- Quantification of mild trauma brain injury risk, Biomechanical Analysis of Head Impact Forces
- Where
- Czechia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Motor Activity
The Influence of Laterality on the Performance of Healthy Women in Selected Standardized Tests
The aim of the research study is to find out how the results of healthy women aged 20-24 years (inclusive) differ in the Nine Peg Test, the Purdue Pegboard Test and the Box and Block Test, depending on the laterality of the…
- Trial name
- NCT05661617
- Testing
- Nine Hole Peg Test, Purdue Pegboard Test, Box and Block Test
- Where
- Czechia
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
CSF Leak, CSF Pressure Increased
Conservative vs Interventional Management of Postsurgical CSF Pseudomeningocele
Dear Sir or Madam, You have been invited to participate in a clinical study whose aim is to compare the effectiveness of two different approaches to the treatment of cerebrospinal fluid (CSF) pseudomeningocele - conservative…
- Conditions
- CSF Leak, CSF Pressure Increased, CSF Circulation Disorder, Puncture
- Trial name
- PSEUDO (NCT07614399)
- Testing
- Lumbar Drainage, Pseudomeningocele Puncture, Puncture with Fibrin Glue Application
- Where
- Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Crohn Disease, Ulcerative Colitis
The Effect of VSL#3 Probiotic Preparation on the Bile Acid Metabolism in Patients With Inflammatory Bowel Disease
The aim of the study is to determine, whether administration of VSL#3 (Original De Simone formulation) probiotic preparation can alter the bile acid metabolism in patients with inflammatory bowel disease.
- Trial name
- NCT01765439
- Testing
- VSL#3 (Original De Simone formulation)
- Where
- Czechia
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Hip Injury
Development of a Certified Testing Procedure for Hip and Groin Injuries in Athletes
Hip and groin injuries affect approximately 21% of professional athletes annually, causing significant time loss. As roughly 48% of these cases result from non-contact mechanisms, they are potentially preventable through…
- Trial name
- NCT07525154
- Testing
- Strength-focused, Flexibility-focused
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Muscle Architecture, Ultrasonic Diagnosis
Feasibility and Preliminary Effects of a Structured Resistance Training Program in Children Aged 10-14 Years
This study is a randomised controlled pilot trial designed to evaluate the feasibility, safety, and preliminary efficacy of a 12-week resistance training intervention in children aged 10-14 years.
- Trial name
- NCT07512570
- Testing
- Progressive Resistance Training Program
- Where
- Czechia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Motor Activity
Variability of Healthy People and People After Stroke Results in the Nine Hole Peg Test
Main aim of the study is to find out how many attempts of each subtest in the Nine Hole Peg Test should be done in clinical practice during testing people after stroke who are 20-64 years old.
- Trial name
- NCT06395597
- Testing
- Nine Hole Peg Test
- Where
- 2 sites in Czechia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Motor Activity
Establishing of the Inter-rater Reliability and Variability of Selected Standardized Tests Performed in Czech Language
The main aim of the pilot project is to establish inter-rater reliability, internal variability and variability of results got in two different ways of the Nine Hole Peg Test, Purdue Pegboard Test and Box and Block Test…
- Trial name
- NCT04967677
- Testing
- Nine Hole Peg Test, Purdue Pegboard Test, Box and Block Test
- Where
- Czechia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Physical Inactivity, Obesity & Overweight
Development of Human Motor Skills and the Promotion of Motivation for Physical Activity
This study is conducted within the University Centre of Excellence for Studies of Human Motoric at the Faculty of Physical Education and Sport, Charles University.
- Conditions
- Physical Inactivity, Obesity & Overweight, Motor Development, Cognitive Development
- Trial name
- NCT07485270
- Testing
- E-MOVE - Emotional Movement Program for Physical Education
- Where
- 9 sites in Czechia
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Lactating Women - Human Milk Donors
Single-center Evaluation of Human Milk Quantity and Quality Over Five Years
This single-center retrospective observational study includes all human milk donors collaborating with the milk bank at České Budějovice Hospital between 2021 and 2025.
- Trial name
- HUMBLE (NCT07309146)
- Testing
- No Interventions
- Where
- Czechia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Systemic Inflammatory Response Syndrome (SIRS)
Myostatin and Irisin Levels in Predicting the Outcome of Patients With Systemic Inflammation: A Prospective Observational Study
Systemic inflammatory response syndrome (SIRS) is associated with severe metabolic stress that can lead to rapid breakdown of skeletal muscle and the development of stress-related malnutrition.
- Trial name
- NCT07476391
- Where
- Czechia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Ear Noise, Tinnitus, Noise Induced
Multimodal Therapy for Somatosensory Tinnitus
Tinnitus (ringing or buzzing in the ears) affects approximately 10-15% of the adult population and significantly reduces quality of life in many patients.
- Conditions
- Ear Noise, Tinnitus, Noise Induced, Tinnitus, Subjective, Headache Other
- Trial name
- SOMATIN (NCT07468318)
- Testing
- Multimodal physiotherapy for TMJ and Cervical spine, Combined Exercise Program (Aerobic + Resistance + Breathing), Tinnitus-Specific Psychological Support
- Where
- Czechia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Menstrual Cycle, Physical Performance
Menstrual Cycle and Women's Performance
This study examines how different phases of the menstrual cycle are associated with selected performance and musculoskeletal parameters in physically active women aged 18-35 years.
- Conditions
- Menstrual Cycle, Physical Performance, Muscle Strength, Musculoskeletal System
- Trial name
- NCT07462286
- Testing
- Menstrual Cycle Tracking, Performance and Strength Testing, Musculoskeletal Assessment
- Where
- Czechia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Low Back Pain, Postural
Functional Pathologies of the Musculoskeletal System in Physiotherapy Students
This study map the occurrence of functional pathologies of the musculoskeletal system in students of the bachelor's program of physiotherapy of the Third Faculty of Medicine, Charles University, and aim on improvement of them.
- Trial name
- FUNPAMUS (NCT05544188)
- Testing
- Differential diagnostic
- Where
- Czechia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Catabolic State, Burns
Illusory Movements in Patients With Burns
Background. Large burns are the cause of extensive skeletal muscle devastation. The possibilities of rehabilitation of such patients are very limited, which contributes to the risk of metabolic failure and long-term…
- Conditions
- Catabolic State, Burns, Illusions, Kinesthetic
- Trial name
- Immobile (NCT04467619)
- Testing
- Functional Proprioceptive Stimulation
- Where
- Czechia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
NO DECOMPENSATED ILLNESS, Muscle Cramps
The Relationship of the Joint Blockage and Muscle Spasm
An interventional study aimed at verifying the effect of sacroiliac joint blockage on changes in piriformis muscle tension. The study was conducted on 40 subjects, both male and female.
- Conditions
- NO DECOMPENSATED ILLNESS, Muscle Cramps, Joint Dysfunction
- Trial name
- NCT07264530
- Testing
- Mobilization technique for sacroiliac joint
- Where
- Czechia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Varicose Veins of Lower Limb, Spider Veins
CLaCS Using 0.2% Aetoxysklerol Foam and 70% Glucose for the Treatment of Lower Limb Telangiectasias
This randomized, controlled, non-inferiority trial aims to compare the efficacy of two sclerosants used in the CLaCS (CryoLaser and CryoSclerotherapy) method for treating telangiectasias and reticular varicose veins.
- Conditions
- Varicose Veins of Lower Limb, Spider Veins, Reticular Leg Veins
- Trial name
- CLACSO (NCT07073742)
- Testing
- CLaCS
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Adenomyosis, Fibroid Uterus
Fertility Limiting Diseases of Pelvic Organs and Their Influence on Receptivity of Endometrial Cavity: Prospective Clinical Trial
In this project, we will characterize the effects of fertility limiting diseases of pelvic organs on the receptivity of the endometrium.
- Conditions
- Adenomyosis, Fibroid Uterus, Endometriosis
- Trial name
- REAdME (NCT06991595)
- Testing
- cytoreductive resection of adenomyosis, myomectomy, resection of endometriosis, hysteroscopy
- Where
- Czechia
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Artificial Intelligence
Conversational AI in Tactical Casualty Care: Baseline GPT-4o Improves Combat Medic Decision-Making
The aim of the project is to investigate whether the integration of artificial intelligence (AI) support, specifically through the GPT-4 model, enhances the decision-making processes of military medical first responders within…
- Trial name
- FieldAI (NCT06796036)
- Testing
- Combat Medic Decision-Making with and without artificial intelligence assistance
- Where
- Czechia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Eating Disorder, Bulimia Nervosa
Co-Feedback Action of Growth Hormone, PP and PYY on Ghrelin in Bulimia
This study evaluates the addition of Acipimox or placebo to exercise on growth hormone release and ghrelin secretion in bulimic patients and in healthy women.
- Trial name
- NCT03338387
- Testing
- Acipimox
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic