Clinical trials: Caffeine, completed
Atopic Dermatitis
Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis
The primary objective of the study is to evaluate the pharmacokinetics (PK) of multiple cytochrome P450 (CYP450) substrates alone and in combination with rocatinlimab in participants with moderate to severe atopic dermatitis (AD).
- Trial name
- NCT05891119
- Testing
- Caffeine, Metoprolol, Midazolam
- Where
- 7 sites in United States
- Volunteers
- 21 people
- Sponsor
- Amgen
Ileostomy - Stoma
Cocoa Ileostomy Study
There is substantial interest in the potential role of chocolate and its primary bioactive component; flavan-3-ol, (-)-epicatechin, in both the prevention and management of cardiovascular disease (CVD).
- Trial name
- NCT03765606
- Testing
- Cocoa Flavanol beverage mix, De-xanthinated Cocoa Flavanol beverage mix
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ulster
AOD Effects and Consequences
Effect of Acute Ethanol Consumption on The Activity of Major Cytochrome P450 Enzymes, NAT2 and P-glycoprotein
Protocol title: Effect of acute alcohol consumption on the activity of major cytochrome P450 enzymes, NAT2 and P-glycoprotein. Objectives: The study is mainly conducted to evaluate the effect of acute alcohol consumption on the…
- Trial name
- NCT02515526
- Testing
- caffeine, tolbutamide, omeprazole, dextromethorphan, digoxin, midazolam single doses, ethanol multiple doses plus caffeine, tolbutamide, omeprazole, dextromethorphan, digoxin, midazolam single doses
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Cologne
Caffeine
Caffeine and Cerebrovascular Reactivity
Caffeine is the most commonly used stimulant drug with well documented effects on cerebral vascula-ture. Caffeine is known to non-specifically bind to adenosine receptors in the brain and to reduce resting blood flow while…
- Trial name
- NCT04730193
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Healthy Volunteer
Occupancy of Adenosine A2A Receptors Using the PET Radiotracer [18F]MNI-444
The overall goal of this protocol is to evaluate the binding of caffeine to adenosine A2A receptors in the brain of participants at risk for developing PD.
- Trial name
- NCT05009199
- Testing
- [18F]MNI-444
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Invicro
Alertness
Evaluating the Impact of Energy Drink Formulas on Alertness for an Extended Period
The primary purpose of the research is to evaluate in healthy adults the time course effects of energy drink formulas containing 120 mg caffeine with varying levels of taurine and b vitamins on subjective alertness in the…
- Trial name
- NCT07400614
- Testing
- All beverages are flavor and color matched, Flavored carbonated beverage, color-matched
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Clinical Deterioration, Hospital Medicine
Realtime Streaming Clinical Use Engine for Medical Escalation
The escalation of care for patients in a hospitalized setting between nurse practitioner managed services, teaching services, step-down units, and intensive care units is critical for appropriate care for any patient.
- Conditions
- Clinical Deterioration, Hospital Medicine, Monitoring, Physiologic
- Trial name
- ReSCUE-ME (NCT04026555)
- Testing
- MEWS++ Monitoring, Predictor Score
- Where
- United States
- Volunteers
- 2,780 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Prematurity, Respiratory Failure
Non-invasive Neurally Adjusted Ventilatory Assist Versus Nasal Intermittent Positive Pressure Ventilation for Preterm Infants After Extubation
Non-invasive respiratory support has been emerging in the management of respiratory distress syndrome (RDS) in preterm infants to minimise the risk of lung injury.
- Conditions
- Prematurity, Respiratory Failure, Ventilator Lung; Newborn
- Trial name
- NCT03388437
- Testing
- NI-NAVA, NIPPV
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- King Fahad Armed Forces Hospital
Muscle Hypotrophy, Exercise Performance
Resistance Training Adaptations and Caffeine Intake
This parallel-group, randomized, double-blind, placebo-controlled trial investigates the effects of three different caffeine supplementation strategies on resistance training-induced adaptations in 120 caffeine-naive, inactive…
- Conditions
- Muscle Hypotrophy, Exercise Performance, Muscle Strength, Adaptation
- Trial name
- NCT07410195
- Testing
- Caffeine (Constant Daily Dose), Caffeine (Escalating Dose), Caffeine (Training Days Only)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Parkinson's Disease
Caffeine as a Therapy for Parkinson's Disease
Parkinson's disease is a common neurodegenerative disorder in which patients experience progressive motor disability and many disabling non-motor symptoms.
- Trial name
- NCT01738178
- Testing
- Caffeine
- Where
- 8 sites in Brazil, Canada
- Volunteers
- 119 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Obesity
Effect on Energy Metabolism at Cellular Level of Diet Plus Treatment With Ephedrine and Caffeine in Obesity
Brief Summary This trial was part of a sub-project targeted to diet, thermogenesis and obesity of a larger multicentre study named "Interaction between nutritional, social-behavioral and metabolic factors for prevention of…
- Trial name
- NCT02048215
- Testing
- Caffeine, Ephedrine, Hypocaloric diet
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Istituto Auxologico Italiano
Osteoporosis, Diet Habit
Soft Drinks and Osteoporosis in WHI Participants
Osteoporotic fractures, as a consequence of a reduced mineral bone density (BMD) represents a major public health problem. The lifetime risk of fractures exceeds 40% for women and 13% for men.
- Trial name
- NCT03371433
- Testing
- Soft drinks
- Volunteers
- 79,885 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Frailty
Autonomy Among Physically Frail Older People in Nursing Homes
The purpose of this study is to assess the status of perceived autonomy and to evaluate the effectiveness of individually tailored programmes on perceived autonomy in physically frail older people living in nursing homes.
- Trial name
- NCT00783055
- Testing
- Individually tailored programmes
- Where
- Denmark
- Volunteers
- 66 people
- Sponsor
- University of Southern Denmark
Supportive Care, Cancer
Feasibility Study of the Advanced Symptom Management System (ASyMS) in Canadian Cancer Patients
The Advanced Symptom Monitoring and Management System - Canada (ASyMS-Can) is a remote phone-based symptom management system that prompts patient self-care and clinician telephone triage and intervention based on alerts for…
- Trial name
- ASyMS-Can (NCT03335189)
- Testing
- ASyMS-Can
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- University Health Network, Toronto
Oral Hygiene, Oral Health
Oral Hygiene Among Portuguese Older Adults
The goal of this clinical trial was to compare two different oral hygiene instruction methods on oral hygiene behavior in older adults.
- Conditions
- Oral Hygiene, Oral Health, Older
- Trial name
- NCT06444490
- Testing
- General Approach Instruction, Personalised Technique Instruction
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Overweight, Obese
The Impact of Integrating an Internet Weight Control Program Into Primary Care
The investigators will conduct a randomized controlled trial comparing the effects of three interventions on weight loss at 12 months.
- Trial name
- NCT01606813
- Testing
- Usual Care, Brief Physician Counseling, Referral and access to an internet weight control program
- Where
- United States
- Volunteers
- 611 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Endotoxemia
A Possible Therapeutic Role for Adenosine During Inflammation
The adenosine receptor is known for its anti-inflammatory actions and could therefore be a potential target in the treatment of sepsis and septic shock.
- Trial name
- NCT00513110
- Testing
- AMPD1 polymorphism, Caffeine infusion
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
RSV Infection, Drug Drug Interaction
A Study to Evaluate the Drug-Drug Interaction of EDP-323 With Midazolam, Caffeine, and Rosuvastatin in Healthy Participants
The primary aim of this study is to assess the effect of EDP-323 on the pharmacokinetics and safety of midazolam, caffeine, and rosuvastatin in healthy adult participants.
- Trial name
- NCT06917508
- Testing
- EDP-323, Midazolam, Caffeine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
Bipolar Disorder (BD)
Project MOVE Bipolar
The investigators propose a randomized clinical trial in which 24 individuals with bipolar disorder are assigned to one of three arms, with each successive arm having an added component that may serve to increase and maintain…
- Trial name
- NCT07767032
- Testing
- BA, SHE, HE
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Butler Hospital
Drug Mechanism, Metabolism Medication Toxicity
Pharmacology Space Kit (PSK) - Dried Blood Spot for Caffeine Pharmacokinetics Under Microgravity Conditions
The PSK study is preliminary to the study of drug metabolism in space flight conditions. The investigators propose to use simplified blood sampling methods that can be applied in microgravity.
- Conditions
- Drug Mechanism, Metabolism Medication Toxicity, Space Motion Sickness
- Trial name
- PSK (NCT06431984)
- Testing
- prick test
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France