Clinical trials: Caffeine, completed
Adolescent Idiopathic Scoliosis
Oral Caffeine Use for Pain Management in AIS Patients After Spinal Fusion
Prospective, randomized control trial To determine if oral caffeine decreases the frequency of opioid demand in children with adolescent idiopathic scoliosis after their spinal fusion surgery To compare pain scale ratings, number…
- Trial name
- NCT04950660
- Testing
- Caffeine Tablet
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Children's Mercy Hospital Kansas City
Caffeine Dependence, Anxiety
Remote Guided Caffeine Reduction
The purpose of this online research study is to determine whether or not a gradual caffeine reduction program developed at Johns Hopkins can help people reduce their caffeine use.
- Conditions
- Caffeine Dependence, Anxiety, Sleep Disturbance, Gastrointestinal Dysfunction
- Trial name
- NCT04560595
- Testing
- Caffeine Reduction Manual
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Beetroot Juice, Caffeine
Acute Effects of Beetroot Juice and Caffeine Co-ingestion on Lower-limb Strength and Muscular Endurance in Females
The aim of this study is to evaluate the acute effects of beetroot juice and caffeine, consumed individually or in combination, on lower-limb strength and muscular endurance in physically active women.
- Conditions
- Beetroot Juice, Caffeine, Placebo, Beetroot Juice with Caffeine Co-ingestion
- Trial name
- NCT06758323
- Testing
- Beetroot juice combined with caffeine (COM)
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Jose Manuel Jurado Castro
Drug Interaction
A Trial to Evaluate the Impact of C21 on the Exposure of 4 Substrates in Healthy Volunteers
This is a single-centre, open-label, fixed-sequence trial to evaluate the impact of C21 on the exposure of CYP1A2, CYP2C9, CYP3A4 and P-gp substrates in healthy volunteers.
- Trial name
- NCT05830799
- Testing
- Drug Drug Interaction
- Where
- Sweden
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Vicore Pharma AB
Caffeine, Control
Caffeinated Chewing Gum & Wrestling Performance
The purpose of this study was to investigate the effect of caffeinated chewing gum on sympathetic nerve activity on wrestling simulation match.
- Trial name
- NCT06758336
- Testing
- caffeine
- Where
- Taiwan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Influenza
High-risk Influenza Vaccine Alert
The purpose of this study is to assess, prospectively, the effect on flu vaccination rates of salient alerts in the electronic health record that indicate a patient's high risk for flu and its complications.
- Trial name
- NCT05492786
- Testing
- Alert, Salient alert features, High-risk Text
- Where
- United States
- Volunteers
- 80,452 people
- Sponsor
- Geisinger Clinic
Coronary Artery Disease (CAD)
Caffeine's Effect on Regadenoson Administration With Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)
Observe whether the administration of caffeine prior to regadenoson will affect the interpretation of test results in subjects with coronary artery disease (CAD) undergoing SPECT MPI
- Trial name
- NCT00826280
- Testing
- regadenoson, overencapsulated caffeine, technetium
- Where
- 25 sites in United States
- Volunteers
- 347 people
- Sponsor
- Astellas Pharma Inc
Substrate Oxidation, Energy Expenditure
Exercise-Induced Rates of Fat Oxidation with and Without Ingestion of a Caffeine-Based Energy Drink
The purpose of this study is to evaluate acute changes in rates of fat oxidation during exercise with and without the ingestion of a caffeine-based energy drink.
- Conditions
- Substrate Oxidation, Energy Expenditure, Reaction Time, Cognition
- Trial name
- EDX (NCT06308731)
- Testing
- Caffeine-Based Energy Drink
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Healthy Volunteers
Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate
Background: Changes in how a person's body burns energy or calories can affect their weight over time. The lowest level of energy the body needs to function is called basal metabolic rate.
- Trial name
- NCT01950520
- Testing
- Propranolol, Pindolol, Dantrolene
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hypercapnia
Influence of Caffeine on Psychomotor Vigilance and Carbon Dioxide Tolerance During Graded Hypercapnia
The aim of this randomized, double-blind, placebo-controlled crossover trial is to determine the effects of caffeine vs. placebo on psychomotor vigilance and carbon dioxide tolerance during graded hypercapnia.
- Trial name
- C3F (NCT06636825)
- Testing
- Graded hypercapnia, Caffeine
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Behavioral Pharmacology of Cannabinoids
The Pharmacodynamics of Cannabinoid-Caffeine Combinations
Cannabis and caffeine are two of the most commonly consumed psychoactive substances in the world, with many consumers reporting positive impacts on energy, alertness, and focus.
- Trial name
- NCT05478863
- Testing
- Oral THC, Oral CBD, Oral Caffeine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Exercise
Caffeine Supplementation on Movement Patterns and Reactive Agility in Rugby Sevens Matches
Caffeine is widely used by rugby players for its performance-enhancing effects. The main questions it aims to answer are: (1) the impact of caffeine supplementation on various performance metrics, including distance covered at…
- Trial name
- NCT06612463
- Testing
- Caffeine 6mg/kg
- Where
- Taiwan
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Esports, Caffeine
Effects of Caffeine, L-Theanine, and Diaphragmatic Breathing on Esports Players' Performance
The purpose of this study is to investigate whether caffeine, L-theanine (a natural amino acid found in tea), and diaphragmatic breathing exercises can help improve the game performance of esports players.
- Conditions
- Esports, Caffeine, L-theanine
- Trial name
- CLD Esports St (NCT06621797)
- Testing
- Intervention 1: Dietary Supplement - Caffeine Supplement, Intervention 2: Dietary Supplement - Caffeine + L-Theanine Supplement, Intervention 3: Dietary Supplement - Caffeine Supplement + Diaphragmatic Breathing Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Advanced Solid Tumors, Metastatic Melanoma
Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors
This is an open-label, 3-arm, fixed-sequence study to evaluate the effect of single and multiple oral doses of encorafenib in combination with binimetinib on the single oral dose pharmacokinetics (PK) of cytochrome P450 (CYP)…
- Trial name
- NCT03864042
- Testing
- losartan, dextromethorphan, caffeine
- Where
- 29 sites in United States, Belgium and 3 more
- Volunteers
- 56 people
- Sponsor
- Pfizer
Caffeine and Resistance Training
Caffeine and Resistance Training in Young Adults
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance.
- Trial name
- NCT06610136
- Testing
- Caffeine plus Resistance training
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Caffeine
Caffeine, Resistance Exercise and EMG
Introduction: Several studies have evaluated and confirmed the ergogenic effects of acute caffeine intake on sports performance.
- Trial name
- NCT06606652
- Testing
- Caffeine
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Dietary Supplements, Caffeine
Effect of Acute Caffeine and Beetroot Juice Intake on Strength, Power, and Muscular Endurance
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine and beetroot juice intake on sports performance.
- Conditions
- Dietary Supplements, Caffeine, Nitrates, Sports Performance
- Trial name
- CAF+BJ (NCT06596395)
- Testing
- Acute caffeine and beetroot juice, Acute caffeine, Acute beetroot juice
- Where
- Spain
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Caffeine, Balance; Distorted
The Effect of Turkish Coffee on Postural Control and Hand-eye Coordination in Young Adults
Although the effects of different doses of caffeine on balance have been evaluated in various studies, the effects of low doses of caffeine ingested with Turkish coffee on postural control and hand-eye coordination remain…
- Conditions
- Caffeine, Balance; Distorted, Coordination and Balance Disturbances
- Trial name
- NCT06561113
- Testing
- Caffeine intake
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Rheumatoid Arthritis
Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19 and CYP3A4
Olokizumab (OKZ) has been shown to reverse the inhibitory effect of IL-6 on the activity of Cytochrome P450 (CYP450) isozymes CYP1A2, CYP2B6, CYP2C9, CYP2C19, and CYP3A4/5 in vitro.
- Trial name
- NCT04246762
- Testing
- Olokizumab, Omeprazole, Caffeine
- Where
- 2 sites in Bulgaria, Moldova
- Volunteers
- 17 people
- Sponsor
- R-Pharm International, LLC
Caffeine, Hypoxia
Caffeine and Hypoxia During Exercise in Males and Females
Several high-altitude destinations recommend their visitors to avoid caffeine, theoretically due to the associated diuresis which could contribute to acute mountain sickness.
- Trial name
- HypoCaff (NCT05764018)
- Testing
- Caffeine, Hypoxia, Normoxia
- Where
- Slovenia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute