Clinical trials: sponsored by Al-Azhar University
Metformin Gel, Bone Healing
Effect of Metformin Gel on Guided Bone Regeneration Around Immediate Dental Implant at Posterior Maxillary Region
To evaluate, by standardized radiographic follow-up, whether locally delivered 1% metformin gel improves bone healing around immediately placed dental implants augmented with GBR.
- Conditions
- Metformin Gel, Bone Healing, Guided Bone Regeneration, Crestal Bone Loss
- Trial name
- MET-GBR (NCT07770087)
- Testing
- Metformin 1% Topical Gel, immediate Dental Implant Placement With Guided Bone Regeneration
- Where
- 2 sites in Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Renal Stone Disease, Ureteral Stricture
Long-term Safety of UAS-assisted vs Sheathless RIRS in Non-prestented Patients
This retrospective comparative cohort study will include adult patients who underwent primary RIRS for renal stones ≤20 mm at Al-Azhar University Hospitals between January 2020 and December 2025.
- Conditions
- Renal Stone Disease, Ureteral Stricture, Hydronephrosis, Urolithiasis
- Trial name
- NCT07767773
- Testing
- Ureteral access sheath-assisted RIRS, Sheathless RIRS
- Where
- Egypt
- Volunteers
- 1,200 people
- Sponsor
- Al-Azhar University
Urethral Stricture
Factors Predicting Urethral Stricture Recurrence After Dorsal Onlay Augmented, Buccal Mucosal Graft Urethroplasty
In this observational study, the investigators will evaluate potential risk factors associated with urethral stricture recurrence after augmentation anterior urethroplasty using dorsal onlay buccal mucosal Graft during the past…
- Trial name
- NCT04357080
- Testing
- Urethroplasty
- Where
- Egypt
- Volunteers
- 266 people
- Sponsor
- Al-Azhar University
Kidney Calculi, Radiation Exposure
Safety and Efficacy of Fluoroscopy-free Technique During Retrograde Intrarenal Surgery for Renal Stones
Aiming to reduce radiation exposure to patients and physicians, the investigators conduct this study protocol to evaluate the possibility of performing retrograde intrarenal surgery (RIRS) under direct visualization without…
- Conditions
- Kidney Calculi, Radiation Exposure, Retrograde Intrarenal Surgery
- Trial name
- NCT05269108
- Testing
- Fluoroscopy-free RIRS, Standard RIRS
- Where
- Egypt
- Volunteers
- 503 people
- Sponsor
- Al-Azhar University
Renal Stone, Percutaneous Nephrolithotomy
Mini-PNL, RIRS, and ESWL for Treatment of Medium-Sized, High-Density, Non-Lower Pole, Renal Stones
The optimal management of medium-sized renal stones remains quite challenging and continues to be contested. In the present study, the investigators will compare mini-PNL, RIRS and SWL in the treatment of non- lower pole, medium…
- Conditions
- Renal Stone, Percutaneous Nephrolithotomy, Retrograde Intrarenal Surgery, Extracorporeal Shockwave Lithotripsy
- Trial name
- NCT04856722
- Testing
- mini-PNL, RIRS, SWL
- Where
- Egypt
- Volunteers
- 253 people
- Sponsor
- Al-Azhar University
Renal Stone, Extracorporeal Shockwave Lithotripsy
Mini- Percutaneous Nephrolithotomy Versus Extracorporeal Shock Wave Lithotripsy for High Density Renal Stones
Several studies were conducted to compare extracorporeal shockwave lithotripsy (SWL) and percutaneous nephrolithotomy (PNL) as treatment options for medium size lower caliceal high dense stones.
- Conditions
- Renal Stone, Extracorporeal Shockwave Lithotripsy, Percutaneous Nephrolithotomy
- Trial name
- NCT04346134
- Testing
- mini-PNL, SWL
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Al-Azhar University
Erectile Dysfunction, Metabolic Syndrome
Lifestyle Modification for Erectile Dysfunction in Men With Metabolic Syndrome
Metabolic syndrome is associated with erectile dysfunction through obesity, insulin resistance, abnormal blood lipids, high blood pressure, and impaired blood-vessel function.
- Trial name
- LIFE-MetS-ED (NCT07758842)
- Testing
- Structured Lifestyle Modification Program
- Where
- 2 sites in Egypt
- Volunteers
- 55 people
- Sponsor
- Al-Azhar University
Renal Calculi, Renal Anomaly
RIRS for Treatment of Stones in Congenital Anomalous Kidneys
The anatomic renal abnormalities like altered spatial relations with adjacent organs, abnormal calyceal orientation, and anomalous vascular patterns make the active treatment of stones in the congenitally malformed kidney a great…
- Trial name
- NCT05240170
- Testing
- RIRS, SWL
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Al-Azhar University
Bonding
Bond Strength Evaluation
This study was evaluated the effect of dimethyl sulfoxide pretreatment on tensile bond strength and nanoleakage of resin composite bonded to aged dentin.
- Trial name
- DMSO (NCT07196618)
- Testing
- dimethyl sulfoxide, Cholorhexidine
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Al-Azhar University
Acanthosis Nigricans
Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans
evaluate and compare the clinical Efficacy \& Safety Of Fractional Carbon Dioxide (Co₂) Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans.
- Trial name
- NCT07760181
- Testing
- Topical metformin
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Frontal Sinusitis, Endoscopic Sinus Surgery
Radiological and Surgical Analysis of Frontal Recess Variations in Endoscopic Sinus Surgery
Introduction The frontal recess is a narrow and anatomically variable region that forms the frontal sinus drainage pathway. Variations in its anatomy, particularly those related to the agger nasi cell and other frontal recess…
- Conditions
- Frontal Sinusitis, Endoscopic Sinus Surgery, Frontal Sinus Recess
- Trial name
- NCT07748806
- Testing
- endosocpic sinus surgery
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Cervical Disc Disease
Clinical and Radiological Outcomes of Anterior Cervical Discectomy and Fusion by Zero Profile Anchored Cage for Cervical Degenerative Disc Disease
The incidence of degenerative cervical conditions is increasing with the aging population, and it is well-recognized as a primary cause of myelopathy, radiculopathy, and disc herniation.
- Trial name
- NCT07743801
- Testing
- Anchored cage for CDD
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Al-Azhar University
Skeletal Class II Malocclusion, Skeletal Class III Malocclusion
Clinical and Radiographic Evaluation of Low Sagittal Medial Ramus Osteotomy for Treatment of Skeletal Class II and Class III Malocclusion
This prospective clinical trial aims to evaluate the clinical and radiographic outcomes of the low sagittal medial ramus osteotomy-a technical modification of the conventional sagittal split osteotomy (SSO)-for treating patients…
- Conditions
- Skeletal Class II Malocclusion, Skeletal Class III Malocclusion, Dentofacial Deformities
- Trial name
- NCT07746700
- Testing
- Low Sagittal Medial Ramus Osteotomy
- Volunteers
- 11 people
- Sponsor
- Al-Azhar University
Dental Crowding, Malocclusion, Angle Class I
The Reliability and Validity of Little's Irregularity Index Assessment
The primary aim of the current study was to estimate the validity, reliability, and repeatability of LII measurements
- Trial name
- LII (NCT07745855)
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Al-Azhar University
Turbinate Hypertrophy, Adenoidectomy
Adenoidectomy With or Without Partial Inferior Turbinectomy for Pediatric Nasal Obstruction
Nasal obstruction is a common problem in children and is frequently caused by adenoid hypertrophy with concomitant inferior turbinate hypertrophy, leading to sleep-disordered breathing and reduced quality of life.
- Conditions
- Turbinate Hypertrophy, Adenoidectomy, Adenoid Hypertrophy, Turbinate Surgery
- Trial name
- NCT07745868
- Testing
- adenoidectomy, Adenodiectomy and bilateral partial infeiror turbienctomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
UTI, Bacterial Colonization
Risk Factors and Clinical Implications of Double-J Ureteral Stent Bacterial Colonization: A Prospective Cohort Study
To identify the risk factors associated with bacterial colonization of Double-J ureteral stents and to evaluate its clinical implications, including bacteriuria, UTI, antimicrobial resistance, and stent-related symptoms.
- Trial name
- NCT07740811
- Testing
- Urine and stent cultures
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Al-Azhar University
BPH With Urinary Obstruction, Prostatic Hyperplasia
Low Power HOLEP Versus TURP
Patients with obstructed flow due to BPH will be enrolled into 2 groups, group will undergo TURP and the other group will undergo Low power HOLEP
- Trial name
- HOLEP vs TURP (NCT07741214)
- Testing
- low power HOLEP, TURP
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Urinary Bladder, Overactive
Low-Intensity Shock Wave Therapy for Refractory Overactive Bladder in Women
Overactive bladder is a condition characterized by a sudden and difficult-to-control need to urinate, which may occur with frequent urination, nighttime urination, and urine leakage.
- Trial name
- NCT07739550
- Testing
- Low-Intensity Extracorporeal Shock Wave Therapy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Psoriasis
Nailfold Capillaroscopic Changes in Psoriasis
The goal of this observational study is to evaluate nailfold capillaroscopic changes in patients with psoriasis and to assess their correlation with disease severity.
- Trial name
- NCT07693595
- Testing
- Nailfold Capillaroscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Bell Palsy
Ultrasound-guided Combined Perineural and Intramuscular Dextrose Injection for Management of Refractory Bell's Palsy
Bell's palsy (BP) is characterized by idiopathic acute weakness of the facial muscles associated with compression of the facial nerve.
- Trial name
- NCT07728331
- Testing
- Ultrasound-guided combined perineural and intramuscular dextrose injection.
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Al-Azhar University