Clinical trials: sponsored by McMaster University
Fibromyalgia
Neurophysiology of Fibromyalgia
Fibromyalgia is a syndrome associated with fatigue and chronic pain, leading to significant physical limitations and impaired quality of life.
- Trial name
- NCT06006130
- Testing
- Active Controlled Pulse Parameter Transcranial Magnetic Stimulation (cTMS)
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Arthroplasty, Replacement, Knee
Testing Regional Anesthesia Techniques for Up and Early Discharge Following Knee Arthroplasty - A Feasibility Study
To assess feasibility of a a trial investigation postoperative patient-reported quality of recovery after total knee arthroplasty (TKA) with periarticular joint injection (PAI) ± single shot adductor canal block with or without…
- Trial name
- TRUE KnORTH 2 (NCT06054750)
- Testing
- Ropivacaine, Normal saline
- Where
- Canada
- Sponsor
- McMaster University
Pain
Photo-biomodulation Therapy for Pain Relief After Caesarean Section
C-sections may result in a lot of pain that is distressing to the mother, and can impact bonding with the baby. Although there are medications used to treat strong pain, they are not good to use after C-sections because they can…
- Trial name
- PBMT (NCT05738239)
- Testing
- Laser therapy
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- McMaster University
Diabetic Neuropathies
Treatment for Diabetic Neuropathy Using Repetitive Transcranial Magnetic Stimulation
The aim of this study is to determine whether a 4-week treatment of repetitive transcranial magnetic stimulation (rTMS) can alleviate the symptoms of neuropathy in individuals with diabetic neuropathy.
- Trial name
- NCT06482827
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- McMaster University
Domestic Violence, Child Maltreatment
RISE With Residents
Prevention of child maltreatment (CM) remains a public health priority in Canada; approximately one-third of Canadians report exposure to at least one form of CM.
- Conditions
- Domestic Violence, Child Maltreatment, Pediatric ALL, Psychiatry
- Trial name
- RISE Residents (NCT05490121)
- Testing
- Violence, Evidence, Guidance, Action Project (VEGA) Education Intervention
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- McMaster University
Eating Disorders
Guided Self Help for Eating Disorders Implementation Study
Eating disorders are amongst the most understudied illnesses affecting young women in Canada. Further, mortality rates are amongst the highest of all psychiatric illnesses.
- Trial name
- GSHimplement (NCT06851273)
- Testing
- Guided Self Help Family Based Therapy (GSH FBT)
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- McMaster University
Eating Disorders
Implementing Virtual Parent Support Groups for Eating Disorders Across Canada
During the COVID-19 pandemic, Canada has experienced a surge in new pediatric eating disorder cases and hospitalizations and long treatment waitlists, with parents experiencing anxiety due to a lack of support.
- Trial name
- vPLPSG (NCT05151900)
- Testing
- Support Group for Caregivers
- Where
- 3 sites in Canada
- Volunteers
- 120 people
- Sponsor
- McMaster University
Diabetic Macular Edema
Treat & Extend Versus Fixed Dosing With Faricimab for Management of Diabetic Macular Edema: A Pragmatic, Multi-center, Open-label, Randomized, Controlled Trial
This study will assess a pragmatic, treat and extend regimen of faricimab against the standard of a fixed dosing regimen.
- Trial name
- INSITE-DME (NCT05610319)
- Testing
- Faricimab
- Where
- 46 sites in United States, Australia and 2 more
- Volunteers
- 446 people
- Sponsor
- McMaster University
Irritable Bowel Syndrome
Biomarkers of Diet-microbiota Interactions in Irritable Bowel Syndrome
Most patients suffering from the irritable bowel syndrome (IBS) report that ingestion of certain foods is a major trigger of symptoms, but the reason is unclear.
- Trial name
- NCT04364750
- Testing
- L-Histidine, High-FODMAP beverage, Low-FODMAP beverage
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Eating Disorders in Adolescence, Transition of Care
Feasibility of the TransitionED Framework for Youth and Young Adults With Eating Disorders
Moving from pediatric (children's) health care to adult health care can be challenging for youth and young adults with eating disorders.
- Trial name
- TransitionED 3 (NCT07518641)
- Testing
- TransitionED Healthcare Transition Framework
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Irritable Bowel Syndrome
Dietary Triggers of Gastrointestinal Symptoms in IBS Patients
This crossover randomized controlled trial will evaluate the effects of purified gluten and whole wheat (gluten combined with amylase-trypsin inhibitors (ATIs)) on inducing intestinal and extra-intestinal symptoms in irritable…
- Trial name
- NCT03664531
- Testing
- Purified gluten, Non-purified gluten (containing ATIs)
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- McMaster University
Juvenile Idiopathic Arthritis, Inflammatory Bowel Diseases
Transition to Adulthood Through Coaching and Empowerment
Pediatric patients with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease who are preparing to transition into adult care face many unique challenges, and, to date, there is no comprehensive and implementable model of…
- Trial name
- TRACE (NCT05570617)
- Testing
- Transition Coach Intervention, Standard of Care- Youth Transition Roadmap
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- McMaster University
Pressure Injuries, Pressure Injury
Using Music During Wound Care Among Seniors With Pressure Injuries
Pressure injuries (also known as pressure wounds or bed sores) are increasingly common among older adults living in care homes. These wounds often require regular dressing changes, which can be uncomfortable for some.
- Conditions
- Pressure Injuries, Pressure Injury, Pressure Ulcer (PU)
- Trial name
- NCT07456618
- Testing
- Music listening
- Where
- 11 sites in Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Sepsis, Critical Illness
Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI)
Phase I dose-escalation safety and feasibility of IV DNase I in ICU septic patients.
- Trial name
- IDEALSepsisI (NCT05453695)
- Testing
- Intravenous DNase I
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McMaster University
Sepsis, Sepsis and Septic Shock
Written Sepsis Education for Patients
This pilot feasibility randomized controlled trial (RCT) aims to determine if it feasible to recruit, deliver, and evaluate a written discharge educational material (a brochure) to adult Intensive Care Unit (ICU) patients…
- Conditions
- Sepsis, Sepsis and Septic Shock, Sepsis at Intensive Care Unit
- Trial name
- NCT07415096
- Testing
- Written Discharge Education, Usual Care
- Volunteers
- 30 people
- Sponsor
- McMaster University
Sepsis, Septic Shock
Fluids in Septic Shock (FISSH)
Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world.
- Trial name
- FISSH (NCT03677102)
- Testing
- higher chloride crystalloid, lower chloride crystalloid
- Where
- 30 sites in Canada, Saudi Arabia
- Volunteers
- 1,113 people
- Sponsor
- McMaster University
Domestic Violence, Veterans Family
RISE With Veteran Service Providers
Veterans and their families are more likely to experience forms of family violence like intimate-partner violence and child maltreatment.
- Conditions
- Domestic Violence, Veterans Family, Veterans, Child Maltreatment
- Trial name
- RISE Vet (NCT05490004)
- Testing
- Violence, Evidence, Guidance, Action Project (VEGA) Education Intervention
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obesity (Disorder)
Evaluation of Food Additive Contributions to Obesity: Pilot Study 1
The effects of food additives on body weight in humans are largely unknown. This is a pilot cross-over double blind RCT in obese adults aimed to test the feasibility of measuring food consumption over 24 hours after one-time…
- Trial name
- NCT07437430
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Child Behavior Problem
Family STEPS: Family Check-Up+
Interventions that promote safe, stable, and nurturing relationships between caregivers and children are key to improving healthy family relationships, reducing child socioemotional and behaviour problems, and preventing child…
- Trial name
- FamilySTEPS (NCT07433361)
- Testing
- Family Check Up
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cerebrovascular Function, Cognition
Ketone Dose and Cerebral Blood Flow Study
Ketone bodies are produced by the liver during periods of food scarcity or severe carbohydrate restriction. Blood ketones are an alternative fuel source used by the brain, heart, and skeletal muscle during periods of fasting.
- Trial name
- kCBF (NCT06032156)
- Testing
- Low Dose β-OHB, High Dose β-OHB
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University