Clinical trials: Acute Cerebrovascular Accident
Stroke
Efficacy of Fluoxetine - a Trial in Stroke
The purpose of this study is to investigate whether routine administration of fluoxetine 20mg once daily in the 6 months initiated during the acute stroke improves the patient's functional outcome.
- Trial name
- EFFECTS (NCT02683213)
- Testing
- Fluoxetine
- Where
- Sweden
- Volunteers
- 1,500 people
- Sponsor
- Karolinska Institutet
Acute Stroke
Early Functional Training in Acute Stroke Inpatient Ward
To investigate the difference between two models of an early intervention program (focused on mobility function) in the functional recovery 3 months post stroke in a group of patients with acute ischemic stroke while in acute…
- Trial name
- NCT04488692
- Testing
- Early intervention (Mobility functional training)
- Where
- Taiwan
- Volunteers
- 142 people
- Sponsor
- Chung Shan Medical University
Stroke
Glial Fibrillary Acidic Protein Testing and Handheld Near Infrared Spectroscopy Technology CEREBO in India.
CEREBO is an ICMR award winning point-of-care (POC) adjunct CT scanning device for detecting brain hematomas in patients with head injury.
- Trial name
- NCT07844109
- Testing
- GFAP/D-Dimer Point-of-Care Testing & CEREBO Near-Infrared Spectroscopy (NIRS), CT Head
- Where
- 2 sites in India
- Volunteers
- 232 people
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Intracranial Aneurysm, AVM - Cerebral Arteriovenous Malformation
Postmarket Study of Tarvos Microguidewire in Neurovascular Interventional Surgery
This investigation is to evaluate the clinical effectiveness and safety of the Tarvos Microguidewire in the neurovascular interventional surgery.
- Conditions
- Intracranial Aneurysm, AVM - Cerebral Arteriovenous Malformation, AV Fistula, Acute Ischemic Stroke
- Trial name
- NCT07500155
- Testing
- Tarvos Microguidewire
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Keuro MedTech
Acute Ischemic Stroke
TWIN2WIN (Double Stent (DS-EVT) Versus Primary Thrombectomy With One Stent (SS-EVT))
The use of a double stent retriever (Dual-SR) has been proposed as a safe and effective technique. The invesigators hypothesized that the use of Dual-SR primary could lead to higher first-pass effect rates and better outcomes…
- Trial name
- NCT05632458
- Testing
- Thrombectomy
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Ischemic Stroke
Remote Ischemic Conditioning for Acute Moderate Posterior Ischemic Stroke
A substantial body of basic and clinical research has demonstrated the protective effects of remote ischemic conditioning (RIC) in ischemic stroke.
- Trial name
- RICAMIS2 (NCT06931535)
- Testing
- remote ischemic conditioning
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- General Hospital of Shenyang Military Region
Spinal Cord Infarction, Spinal Cord Stroke
Descriptive Study of Acute Spontaneous Spinal Cord Infarction
Acute spontaneous Spinal Cord Infarctions (SCI) are an uncommon cause of myelopathy (5%), but their prognostic is heterogeneous and frequently severe. Positive diagnosis is difficult, one quarter of initial MRIs are normal.
- Conditions
- Spinal Cord Infarction, Spinal Cord Stroke, Vascular Myelopathy
- Trial name
- EDMIAS (NCT04372758)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Stroke
Reaching Training Based on Robotic Hybrid Assistance for Stroke Patients ( RETRAINER-S2 )
Stroke is the third most common cause of death and the main cause of acquired adult disability in high-income countries. The most common deficit after stroke is motor impairment of the contralateral arm, with more than 80% of…
- Trial name
- RETRAINER-S2 (NCT03199833)
- Testing
- RETRAINER-S2, Conventional therapy
- Where
- 2 sites in Germany, Italy
- Volunteers
- 68 people
- Sponsor
- Dr. Franco Molteni
Acute Ischemic Stroke
Monosialoganglioside in Acute Ischemic Stroke: a Randomized, Blinded and Multicenter Confirmatory Study
A multicenter, randomized, double-blind, parallel, placebo-controlled trial design is used to evaluate the efficacy and safety of GM1 injection in the treatment of patients with acute ischemic stroke.
- Trial name
- NCT06742216
- Testing
- Monosialoganglioside
- Where
- China
- Volunteers
- 1,232 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Stroke
Effects of Dual-transcranial Direct Current Stimulation During Physical Therapy in Sub-acute Stroke
The aim of the present study is to evaluate the possible effect of using dual-tDCS applied during conventional physical therapy on lower limb function in stroke patients.
- Trial name
- NCT04051671
- Testing
- Transcranial direct current stimulation
- Where
- Thailand
- Volunteers
- 19 people
- Sponsor
- Mahidol University
Stroke
Acute Effects of Whole Body Vibration in Chronic Stroke
Whole body vibration has been found to be useful in promoting bone health, balance, and muscle performance in older adults. The overall aim of the proposed study is to determine whether whole body vibration (WBV) has immediate…
- Trial name
- NCT01211093
- Testing
- High frequency whole body vibration, Low frequency whole body vibration, control
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Hong Kong Polytechnic University
Prehospital Stroke Care
Impact of Prehospital Stroke Care Patterns on Clinical Outcomes in Acute Stroke Patients
This study evaluates how prehospital care factors, including stroke awareness, emergency response, transport, and referral processes, impact patient outcomes in acute stroke cases.
- Trial name
- NCT07198893
- Volunteers
- 125 people
- Sponsor
- Assiut University
Stroke, Acute Ischemic
Endovascular Thrombectomy With and Without Intravenous Thrombolysis in Extended Time Window
The primary hypothesis being tested in this trial is that ischemic stroke patients in large vessel occlusion of anterior circulation at 4.5 - 9 hours post onset of stroke will have improved clinical outcomes when given…
- Trial name
- NCT05634382
- Testing
- Intravenous thrombolysis agents, endovascular thrombectomy
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Ischemic
The Efficacy of Citalopram Treatment in Acute Stroke
We wish to conduct a prospective, randomized, double blind, placebo controlled multi center study of the combined neuroprotective and antithrombotic effects of SSRI treatment after stroke.
- Trial name
- TALOS (NCT01937182)
- Testing
- Citalopram
- Where
- 3 sites in Denmark
- Volunteers
- 642 people
- Sponsor
- University of Aarhus
Ischemic Stroke
Tenecteplase Plus Urinary Kallidinogenase for Acute Ischemic Stroke (TUKIS)
Human urinary kallidinogenase (HUK) is a tissue kallikrein extracted from human urine. Under certain conditions, tissue kallikrein can convert kininogen into kallidin and kinins, thereby promoting vascular endothelial function…
- Trial name
- NCT07283159
- Testing
- Human Urinary Kallidinogenase
- Where
- China
- Volunteers
- 200 people
- Sponsor
- General Hospital of Shenyang Military Region
Stroke, Ischemic
The Effect of The Five-Session Dual-tDCS On Lower-Limb Performance in Sub-Acute Stroke
The aim of the present study is to determine the effect of the five-session dual-tDCS combine with physical therapy on gait performance, balance and lower limbs muscle strength in patients with subacute stroke.
- Trial name
- NCT04287231
- Testing
- Transcranial direct current stimulation
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Mahidol University
Stroke, Stiffness of Right Hand, Not Elsewhere Classified
Relationship Between Upper Extremity' Viscoelastic Properties and Functionality in Subacute Stroke
In stroke patients, the shoulder-upper extremity complex is affected and reduces independence and quality in activities of daily living.
- Conditions
- Stroke, Stiffness of Right Hand, Not Elsewhere Classified, Muscle Tone Abnormalities, Functional; Bleeding
- Trial name
- NCT05920837
- Testing
- MyotonPRO, Box and Block Test
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- University of Gaziantep
Stroke Inflammation
Fingolimod in Endovascular Treatment of Ischemic Stroke
Proof-of concept clinical trials have indicated that the sphingosine-1-phosphate receptor modulator fingolimod may be efficacious in attenuating brain inflammation and improving clinical outcomes in patients with acute ischemic…
- Trial name
- NCT04629872
- Testing
- Fingolimod
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ning Wang, MD., PhD.
Acute Ischemic Stroke
Tenecteplase Compared to Alteplase for Patients With Large Vesel Oclusion Suspicion Before Thrombectomy
Background: The TNKCAT trial represents an innovative approach to optimize timely reperfusion in the Mothership and Drip-and-Ship scenarios.
- Trial name
- NCT05626972
- Testing
- Tenecteplase
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Ischemic Stroke
Plaque Imaging in Routine Care to Detect Intraplaque Hemorrhage
The aim of this study is to investigate the association between intraplaque hemorrhage (IPH) detected by non-contrast magnetic resonance imaging (MRI) of the carotid artery in routine clinical practice and ipsilateral acute…
- Trial name
- PARADE (NCT06749106)
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Ludwig-Maximilians - University of Munich
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