Clinical trials: Advanced Dementia
Dementia
The Hospice Advanced Dementia Symptom Management and Quality of Life Trial (HAS-QOL)
The Aliviado Dementia Care Program (formerly known as the Dementia Symptom Management at Home Program, or DSM-H) was developed to implement dementia friendly care for persons with Dementia and their caregivers living in the…
- Trial name
- NCT04175977
- Testing
- Aliviado Dementia Care-Hospice Edition QAPI program, Usual Care
- Where
- United States
- Volunteers
- 44,143 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Castration-Resistant Prostatic Cancer, Metastatic Prostate Carcinoma
Cognitive Effects of Androgen Receptor Directed Therapies for Advanced Prostate Cancer
This clinical trial studies cognitive function in men with prostate cancer treated with androgen receptor directed therapies such as abiraterone acetate and enzalutamide.
- Conditions
- Castration-Resistant Prostatic Cancer, Metastatic Prostate Carcinoma, Recurrent Prostate Carcinoma, Stage IV Prostate Cancer
- Trial name
- NCT03016741
- Testing
- GnRH agonist/antagonist, Prednisone, Abiraterone Acetate
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Northwestern University
Dementia
Multisensory Stimulation in Dementia.
Dementia is one of the main causes of disability in the elderly. It is characterized by cognitive, functional and social impairment, as well as behavioral changes.
- Trial name
- NCT04008342
- Testing
- Multisensory intervention
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Minas Gerais
Alzheimer Disease, Lewy Body Dementia (LBD)
Deep Cervical Lymphaticovenous Anastomosis Surgery for Moderate-to-Advanced Dementia Patients
This clinical trial aims to evaluate the clinical efficacy and safety of Deep Cervical Lymphaticovenous Anastomosis (DLVA) in patients aged 50-80 with moderate to severe neurodegenerative dementia.
- Conditions
- Alzheimer Disease, Lewy Body Dementia (LBD), Frontotemporal Dementia (FTD), Dementia
- Trial name
- NCT06978946
- Testing
- Deep Cervical Lymphaticovenous Anastomosis(DLVA)
- Where
- China
- Volunteers
- 85 people
- Sponsor
- RenJi Hospital
Neurocognitive Disorders, Alzheimer Disease
Non Verbal Communication and Dementia
Cognitive impairements in Alzheimer's and apparented disorders may lead to the decreased engagement in activities, spetially in moderate and advanced stages of evolution.
- Trial name
- GEMAN (NCT04255329)
- Testing
- Montessori reading roundtable, Usual reading
- Where
- France
- Sponsor
- University Hospital, Montpellier
Lung Cancer, Breast Cancer
Telemedicine-mHealth Symptom Cluster Intervention for Advanced Cancer Patients: Finding Our Center Under Stress (FOCUS)
This clinical trial studies whether a telemedicine-mobile health (mHealth) intervention, Finding Our Center Under Stress (FOCUS), improves symptom management in patients with cancer that may have spread from where it first…
- Conditions
- Lung Cancer, Breast Cancer, Prostate Cancer, Multiple Myeloma
- Trial name
- FOCUS (NCT07102212)
- Testing
- mHealth Intervention
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Multiple Sclerosis, Dry Eye Syndromes
Clinical Applications of Advanced Ophthalmic Imaging
The purpose of this study is to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased…
- Conditions
- Multiple Sclerosis, Dry Eye Syndromes, Diabetic Retinopathy, Presbyopia
- Trial name
- NCT03135327
- Testing
- Ocufolin
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Miami
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Dementia
Withdrawal of Antidementia Drugs in Advanced Dementia (WADAD)
Dementia is a chronic progressive mental disorder that adversely affects higher cortical functions, including cognition and behavior leading up to disability and dependence in daily life activities.
- Trial name
- WADAD (NCT05321680)
- Testing
- Treatment withdrawal
- Where
- Portugal
- Volunteers
- 16 people
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Advanced Dementia, Loss of Medical Decision Making Capacity
Promoting Self-determination for Institutionalized Older People Without Decision-making Capacity: Advance Care Planning by Proxy
This study aims to test the acceptability and feasibility of an advance care planning (ACP) intervention which has been developed to be used with the health care proxies of residential aged care facility (RACF) residents who no…
- Trial name
- PROSPECT (NCT04779684)
- Testing
- Advance care planning by proxy for health care proxies of people without medical decision making capacity
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Ralf J. Jox
Parkinson Disease, Dementia
Application of Smart Electric Vehicles in Analyzing Gait Abnormalities in Patients With Neurodegenerative Diseases
To explore the possibility of smart electric vehicles providing comprehensive gait assistance and improvement for patients with neurodegenerative diseases
- Trial name
- NCT07143006
- Testing
- BestShape Go Intelligent Generation Transformable Electric Vehicle
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Advanced Dementia Stages, Palliative Care
IssuEs in Palliative Care for People in Advanced and Terminal Stages of Young-onset and Late-Onset Dementia in GErmany
From a scientific view, palliative care issues in dementia are neglected in Germany. Neither in Germany nor internationally research has been conducted on palliative care issues in young onset dementia (YOD), although significant…
- Trial name
- EPYLOGE (NCT03364179)
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Technical University of Munich
Advanced Dementia
Advanced Dementia and End-of-life
Palliative and hospice care in advanced dementia: experiences of care givers and benefit of a brochure serving as a decision-making aid Aims: 1.
- Trial name
- NCT03548142
- Testing
- provision of relevant information
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Technical University of Munich
Cancer
Dyadic Life Review Intervention for Older Patients With Advanced Cancer and Alzheimer's Disease and Related Dementias and Their Caregivers
The purpose of this study is to evaluate the efficacy of Dyadic Life Review (DLR) therapy for reducing caregiver distress, measured by caregiver burden to capture the multifaceted experience of distress, among older adults with…
- Trial name
- NCT07796347
- Testing
- Dyadic Life Review
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Rochester
Alzheimer Disease, Dementia
Triggered Palliative Care for Advanced Dementia
The objective of this study is to generate preliminary data for a large multi-site randomized clinical trial of a model of palliative care consultation for patients with advanced dementia, and for their family caregivers.
- Trial name
- NCT02719938
- Testing
- Specialty Palliative Care
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of North Carolina, Chapel Hill
Dementia
Palliative Care at Home for Dementia
The proposed project is a randomized controlled trial of a new home-based palliative care program for adults with advanced dementia and their caregivers within the Mount Sinai Health System.
- Trial name
- NCT03798327
- Testing
- Home Palliative Care
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Dementia, Dementia, Vascular
Advanced Cognitive Stimulation Therapy Hong Kong (ACST-HK)
This study is a feasibility randomized controlled trial (RCT) for an evidence-based intervention for people with moderate to severe dementia in Hong Kong.
- Conditions
- Dementia, Dementia, Vascular, Dementia, Mixed, Dementia With Lewy Bodies
- Trial name
- NCT04555629
- Testing
- Advanced Cognitive Stimulation Therapy Hong Kong
- Volunteers
- 32 people
- Sponsor
- University College, London
Dementia, Hip Pain
Pragmatic Use of PAIN-Advanced Dementia Scale in Emergency Departments
The purpose of this study is to learn if the Pain in Advanced Dementia (PAINAD) scale can improve emergency pain care in persons living with dementia (PLWD).
- Conditions
- Dementia, Hip Pain, Emergency Department Patient, Pain in Advanced Dementia Scale
- Trial name
- NCT06370572
- Testing
- PAINAD EHR Prompt
- Where
- 2 sites in United States
- Volunteers
- 2,421 people
- Sponsor
- University of Chicago
Alzheimer Disease and Related Dementias
Designing Care Management for Hospice Transitions for Persons Living With Advanced Dementia
This study will test a care management intervention to guide end-of-life care and hospice transitions for persons with dementia and their care partners receiving home healthcare and ascertain feasibility, acceptability, fidelity…
- Trial name
- ENGAGE-D (NCT07182357)
- Testing
- Dementia Care Management Checklist for Hospice Transitions
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- New York University
Dementia
Goals of Care: A Nursing Home Trial of Decision Support for Advanced Dementia
This cluster randomized controlled trial is to examine whether decision support for goals of care can improve quality of communication and decision-making and improve the quality of palliative care for nursing home residents with…
- Trial name
- GOC (NCT01565642)
- Testing
- Goals of care decision support
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- University of North Carolina, Chapel Hill