Clinical trials: Cognitive Fatigue, open to volunteers
Post-Treatment Lyme Disease
Transcranial Direct Current Stimulation for Post Treatment Lyme Disease
The primary purpose of this pilot study is to investigate a novel approach to the treatment of cognitive symptoms that persist despite prior antibiotic treatment for Lyme disease (Post treatment Lyme Disease or PTLD).
- Trial name
- NCT06915324
- Testing
- Transcranial Direct Current Stimulation (tDCS), Cognitive training
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Columbia University
Myasthenia Gravis Generalised
Detecting Fatigue From Voice in Generalised Myasthenia Gravis
The goal of this observational study is to learn if computer analysis of voice recordings can detect a type of exhaustion called "central fatigue" in adults with generalised myasthenia gravis.
- Trial name
- NCT07033559
- Volunteers
- 240 people
- Sponsor
- Thymia Limited
Occupational Health, Sleep
Using Cognitive-Behavioral Change and Mobile Technology to Improve RN Sleep and Fatigue
The U.S. registered nurse (RN) workforce is the largest in the Healthcare and Social Assistance Sector and is at high risk for injuries and errors due to poor sleep and fatigue.
- Conditions
- Occupational Health, Sleep, Fatigue, Nurse
- Trial name
- RN-SLEEP (NCT06105307)
- Testing
- RN-SLEEP, Healthy Habit - Educational Control
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Long COVID, Post-COVID Conditions
Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue
Long COVID can cause persistent symptoms such as fatigue, cognitive difficulties commonly described as brain fog, reduced exercise tolerance, and impaired quality of life.
- Conditions
- Long COVID, Post-COVID Conditions, Fatigue, Cognitive Dysfunction
- Trial name
- NEUROSTIM-LC (NCT07709234)
- Testing
- Transcranial Direct Current Stimulation
- Volunteers
- 20 people
- Sponsor
- University of Las Palmas de Gran Canaria
Psychological Stress, Anxiety
NeuroFinance Human Stress Trial During Financial and Informational Volatility
The NeuroFinance Human Stress Trial (NFHST-2026-001) is a decentralized observational clinical study designed to evaluate how financial market volatility, economic uncertainty, digital media exposure, and information-driven…
- Conditions
- Psychological Stress, Anxiety, Emotional Stress, Autonomic Nervous System Dysfunction
- Trial name
- NFHST (NCT07622589)
- Testing
- Wearable Physiologic Monitoring Platform
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Childhood Brain Tumor, Childhood Brain Tumors
The FLaME Cognitive Rehabilitation Study for Childhood Brain Tumour
Medical treatments have improved survival rates for children with brain tumours. However, most children experience long-term difficulties with 'cognition' (thinking skills such as memory and paying attention) and cognitive…
- Conditions
- Childhood Brain Tumor, Childhood Brain Tumors, Pediatric Brain Neoplasms, Pediatric Brain Tumor
- Trial name
- FLaME (NCT06770335)
- Testing
- THE FATIGUE, LEARNING, AND MEMORY ENRICHMENT (FLaME) INTERVENTION - Full intervention, THE FATIGUE, LEARNING, AND MEMORY ENRICHMENT (FLaME) INTERVENTION - Cognitive rehabilitation only
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Cardiac Arrest (CA)
Effects of a Web-based Support Programme for Cardiac Arrest Survivors
The overall goal of this clinical trial is to learn if a web-based support programme can improve wellbeing in cardiac arrest survivors by helping them manage emotional, cognitive, and physical challenges.
- Trial name
- CARDIS (NCT07240714)
- Testing
- Digital Support Programme
- Where
- 9 sites in Sweden
- Volunteers
- 120 people
- Sponsor
- Linkoeping University
Stroke Patients, Stroke
Young Stroke Service Deep Phenotyping: Exploring Recovery in Young Adult Survivors of Stroke
The Investigators are running a small, early-phase research study across several hospitals in Melbourne, Australia. The study will involve up to 100 young adults between the ages of 18 and 55 who have had a stroke.
- Conditions
- Stroke Patients, Stroke, Stroke; Sequelae, Young Adults
- Trial name
- NCT07019493
- Testing
- Observational Cohort
- Where
- 2 sites in Australia
- Volunteers
- 100 people
- Sponsor
- The Florey Institute of Neuroscience and Mental Health
Cognitive Assessment, Working Memory
Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.
The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor.
- Conditions
- Cognitive Assessment, Working Memory, Executive Function (Cognition), Sustained Attention
- Trial name
- NCT07319117
- Testing
- Skoshify 'Think Tank' Formulation
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Multiple Sclerosis, Fatigue in Multiple Sclerosis
Non-invasive Brain Stimulation in Multiple Sclerosis Fatigue
The neurobiological basis of central fatigue in multiple sclerosis remained unclear so far. This study investigates reward-related brain mechanisms, inflammation, and their modulation by non-invasive brain stimulation using fMRI…
- Trial name
- NCT07438964
- Testing
- tDCS of dlPFC
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- Charite University, Berlin, Germany
Mental Fatigue
Music Intervention on Golfers Under Mental Fatigue
This study aims to evaluate the effects of music intervention on golf-specific skill performance under mental fatigue. It is a randomised, controlled, double-blind design.
- Trial name
- NCT06952283
- Testing
- Inducing mental fatigue, Music intervention
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pan Xiaoyang
Multiple Sclerosis
Factorial Optimization Trial to Test Cognitive Behavioral Therapy Components for Multiple Sclerosis Fatigue
This randomized controlled factorial trial will examine whether and how relaxation training, behavioral activation, and cognitive therapy improve fatigue and functioning in fatigued adults living with multiple sclerosis.
- Trial name
- NCT06809192
- Testing
- 4-session Relaxation Training, 4-session Behavioral Activation, 4-session Cognitive Therapy
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Washington
Social Media Addiction
Breaking the Cycle of Social Media Addiction: Efficacy of a 4-STEP Training Program in Reducing Cognitive Fatigue, Psychological Distress, Academic Procrastination, and Burnout Among Adolescents
The goal of this clinical trial is to evaluate the effectiveness of the 4-Step Training Program for Social Media Addiction (4-STEP-TPS) in reducing social media addiction, cognitive fatigue, psychological distress, academic…
- Trial name
- 4-STEP (NCT07821502)
- Testing
- 4-STEP-TPS
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Government College University Faisalabad
Fatigue, Fatigue Post Viral
Characterization, Treatment, and Long-term Follow-up of Fatigued Patients in Primary Care
The overarching purpose of this project is to further the understanding of fatigue as a symptom in primary care patients, and to build evidence for a highly accessible treatment targeting fatigue that can be readily implemented…
- Conditions
- Fatigue, Fatigue Post Viral, Exhaustion Disorder, Fatigue Symptom
- Trial name
- iFAS (NCT06786832)
- Testing
- Cognitive behavioral therapy for persistent fatigue, Care as usual
- Where
- Sweden
- Volunteers
- 190 people
- Sponsor
- Karolinska Institutet
Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting
Sexual Dysfunction in Women With Multiple Sclerosis (MS)
Sexual dysfunction in women with multiple sclerosis (MS) is an important yet often overlooked problem. The primary objective of this study is to investigate the prevalence of sexual dysfunction in female patients diagnosed with…
- Conditions
- Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting, Fatigue in Multiple Sclerosis, Sexual Disfunction
- Trial name
- MS (NCT07193823)
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ege University
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
A 3-day Course for CFS/ME
Chronic fatigue syndrome/Myalgic encephalomyelitis (CFS/ME) can be a serious and disabling condition with a heavy symptom burden and low function. Work disability is common, and social life dramatically affected.
- Trial name
- NCT05236465
- Testing
- A 3-day course, Waiting list
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Norwegian University of Science and Technology
Burnout, Professional
Decision Fatigue and Emotional Exhaustion Among Anesthesiologists
This study aims to evaluate the level of decision fatigue among anesthesiologists actively practicing in clinical settings in Turkey and to examine its relationship with emotional exhaustion.
- Trial name
- NCT07089160
- Testing
- Online Survey (Decision Fatigue Scale and Emotional Exhaustion Scale)
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Istinye University
Cognitive Dysfunction, Acquired Brain Injury
Fareon Open Label Device Clinical Trial
The purpose of this study is to assess the safety and feasibility of an at-home MMT treatment in patients with cognitive dysfunction related to acquired brain injury, Long COVID, traumatic brain injury, myalgic encephalomyelitis…
- Conditions
- Cognitive Dysfunction, Acquired Brain Injury, Traumatic Brain Injury
- Trial name
- NCT07600320
- Testing
- Fareon device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Multiple Sclerosis, Long Covid
Fatigue Investigation Using Digital Outcomes
This study investigates objective methods to measure and monitor fatigue in patients with post-COVID-19 condition (long COVID) and multiple sclerosis (MS), and includes a group of healthy volunteers for comparison.
- Conditions
- Multiple Sclerosis, Long Covid, Healthy
- Trial name
- FIDO (NCT07783074)
- Where
- 6 sites in Switzerland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Liliana Barrios
Cognitive Performance, Attention
Effects of Caffeine on Chess Performance and Cognitive Function in Professional Chess Players
This study will examine whether caffeine improves cognitive and competitive performance in professional chess players during tournament-style games.
- Conditions
- Cognitive Performance, Attention, Reaction Time, Caffeine
- Trial name
- GRANDMASTER (NCT07641335)
- Testing
- Caffeinated Coffee
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- St. Louis University