Clinical trials: Corticospinal Excitability
tDCS, Physical Activity + tDCS
Influence of Physical Exercise on Neuroplasticity and Sensorimotor Networks in Older Adults
The purpose of this study is to investigate the influence of a single session of moderate aerobic exercise on motor cortex neuroplasticity in older adults, both alone and in combination with transcranial direct current…
- Conditions
- tDCS, Physical Activity + tDCS, Physical Inactivity + tDCS
- Trial name
- EXOPLASTIC (NCT07438808)
- Testing
- Aerobic Exercise, Physical Inactivity, Transcranial Magnetic Stimulation
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universite du Littoral Cote d'Opale
Knee Osteoarthritis
Corticospinal Excitability and Rehab in Knee Osteoarthritis
To determine differences in thigh muscle function in individuals with and without knee arthritis, and also determine the effectiveness of common physical therapy interventions on clinical and patient oriented outcomes.
- Trial name
- NCT02036866
- Testing
- Transcutaneous Electrical Nerve Stimulation, Physical Therapy Exercises, No Intervention
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Creighton University
Normoxia, Intermittent Moderate Hypoxia
Brain Connectivity and Corticospinal Excitability in Response to Moderate Hypoxia
Hypoxia, defined as a reduction in the availability of oxygen, induces significant physiological adaptations. While the deleterious effects of severe and chronic hypoxia are well documented, several studies indicate that moderate…
- Conditions
- Normoxia, Intermittent Moderate Hypoxia, Continuous Moderate Hypoxia
- Trial name
- NEUROXIE (NCT07516028)
- Testing
- Moderate hypoxia, Normoxia, Transcranial Magnetic Stimulation
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universite du Littoral Cote d'Opale
Incomplete Spinal Cord Injury
The Effect of Acute Intermittent Hypoxia on Motor Learning
The goal of this study is to examine the effect of repetitive acute intermittent hypoxia on motor learning abilities in able-bodied individuals for subsequent study in individuals with incomplete spinal cord injury.
- Trial name
- NCT05341466
- Testing
- Acute Intermittent Hypoxia
- Where
- 2 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Motor Learning, Corticospinal Excitability
Cortical Excitability During de Novo Motor Learning
De novo motor learning is a specific learning paradigm that allows investigation of how a new motor skill is learned from scratch.
- Trial name
- StimNovoLearn (NCT07455461)
- Testing
- De novo motor learning
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universite du Littoral Cote d'Opale
Resistance Training
Influence of Resistance Training Experience and Mental Imagery on Corticospinal Excitability and Inhibition
This study will utilize transcranial magnetic stimulation (TMS) to examine the effects of mental imagery in resistance-trained versus untrained men and women.
- Trial name
- NCT03889548
- Testing
- Mental Imagery
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
INCOMPLETE SPINAL CORD INJURY (ASIA D), Able Bodied
Examining the Effect of Acute Intermittent Hypoxia on Serum Blood Proteins and Lower Limb Function
The goal of this study is to clarify mechanisms of acute intermittent hypoxia and to examine the effect on lower limb function in persons with chronic, incomplete spinal cord injury.
- Trial name
- NCT06906536
- Testing
- Acute Intermittent Hypoxia (AIH)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Healthy Volunteer
Combining Motor Imagery and Tendon Vibration on the Effectiveness of Motor Imagery
Kinesthetic motor imagery (kMI) involves imagining the sensations of movement, activating brain regions similar to actual movement execution.
- Trial name
- IMVT (NCT06845176)
- Testing
- Tendon vibration (TV), Kinesthetic motor imagery (kMI)
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Shoulder Impingement Syndrome, Chronic Pain
Sensorimotor Cortex Excitability in Shoulder Impingement Syndrome
Shoulder pain is a common musculoskeletal system complaint, accounting for 7-34% of patients in the clinic. The most common shoulder problem is subacromial impingement syndrome (SIS).
- Conditions
- Shoulder Impingement Syndrome, Chronic Pain, Transcranial Magnetic Stimulation, Electroencephalography
- Trial name
- NCT05627986
- Testing
- No intervention
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Corticospinal Excitability, Cortical Activation
LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension
Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research.
- Trial name
- LAMI (NCT06478303)
- Testing
- Motor imagery, Action reading, Motor localizer
- Where
- 2 sites in France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Kinesiophobia, Pain, Acute
Adaptation of the Motor System to Experimental Pain
This study aims to measure the impact of an experimental pain on electromyography, kinematics of motion and motor cortical excitability.
- Trial name
- KinesioPoint (NCT05396820)
- Testing
- Experimental pain
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universite du Littoral Cote d'Opale
Gait
AB Gait Estim Neurophysiology
This study is being done to answer the question: What are the effects of electrical stimulation and stepping practice on connections between the brain and muscles? The long-term goal of this project is to develop novel…
- Trial name
- NCT06430164
- Testing
- Gait Training, Functional electrical stimulation (FES), Peripheral electrical stimulation paired with cortical magnetic stimulation pulses
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Emory University
Hypothermia Due to Cold Environment
Characterization of Corticospinal Excitability During Progressive Skin Cooling
This study characterizes the changes in corticospinal excitability that accompany basic cold stress via skin cooling that result in reduced skin or core temperature and shivering.
- Trial name
- NCT04253730
- Testing
- Cold Stress
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Young Healthy Adults (no Medical Condition/Disease)
Creatine and Motor Skill Acquisition
The investigators will conduct a double-blind, placebo-controlled, repeated measures study of the effects of oral creatine monohydrate supplementation on motor skill acquisition and neurophysiology in young healthy adults.
- Trial name
- NCT05201651
- Testing
- Creatine Monohydrate
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Regina
Nocebo Effect, Kinesiophobia
Effect of Anticipated Pain on Corticospinal Excitability
The purpose of this study is to investigate how the anticipation of pain, in the absence of real pain, affects the excitability of the corticospinal pathway.
- Trial name
- PACE (NCT07407595)
- Testing
- Pain Expectation Manipulation
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universite du Littoral Cote d'Opale
Itch, Pain
Investigation of Corticospinal Excitability Aspects of Itch and Pain
The experiment consists of three experimental sessions conducted over a period of two weeks. In the first experimental session, we apply in your hand: either an injection of salt water (7% NaCl) or we apply small needles from the…
- Trial name
- NCT06470737
- Testing
- Hypertonic Saline, Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Kinesiophobia (Fear of Movement), Experimental Pain
Pain Beliefs and Intracortical Excitability During Experimental Pain
Pain can influence the way the motor system functions. However, responses to pain vary widely between individuals, and this variability may be partly related to pain-related beliefs such as kinesiophobia.
- Trial name
- NCT07688525
- Testing
- Topical Capsaicin Cream (1%)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Instability; Back, Tightness of Back Muscles
Corticospinal Excitability of Deep Back and Abdominal Muscles
This study aims to understand the roles of corticospinal excitability in controlling the trunk movement, and the clinical utility of clinical observation, as well as the effect of lumbopelvic stabilization during hamstrings…
- Trial name
- NCT03747185
- Testing
- Lumbopelvic stiffening technique, Lumbopelvic relaxing technique
- Where
- Thailand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Low Back Pain
Corticospinal and Motor Behavior Responses After Physical Therapy Intervention in Patients With Chronic Low Back Pain.
This study aims to 1) determine the immediate effects of transcranial direct current stimulation (tDCS) on corticospinal excitability, lumbar multifidus muscle (LM) activation, as well as lumbar stability in patients with chronic…
- Trial name
- NCT05156242
- Testing
- Active-tDCS priming MCE, NMES priming MCE, Conventional physical therapy
- Where
- Thailand
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Ultra-marathon Runners
Difference in Central Fatigue During Two Ultra-endurance Practices: Running vs. Cycling
The mechanisms contributing to muscle fatigue in extreme long-duration exercise bouts are poorly understood. Ultra-endurance exercise is an excellent model for the study of adaptive responses to extreme loads and stress and it is…
- Trial name
- FAT-CENTR (NCT04511858)
- Testing
- maximum effort test on a cycloergometer, maximum effort test on a treadmill
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne