Clinical trials: Degenerative Neurologic Disease
Retinal Edema
Suprachoroidal Injection of Triamcinolone Acetonide in Resistant Diabetic Macular Edema, CRVO, Pseudophakic Cystoid Macular Edema and Diabetic Macular Edema Following Pars Plana Vitrectomy
Prospective interventional study on 60 eyes of resistant diabetic macular edema and central retinal vein occlusion that will receive suprachoroidal injection of Triamcinolone Acetonide (SCTA).
- Trial name
- Resistant (NCT04690608)
- Testing
- Triamcinolone Acetonide 40Mg/Ml Inj,Susp_#1
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tanta University
Amyotrophic Lateral Sclerosis, Motor Neurone Disease
Measurement and Impact of Physical Impairment in Amyotrophic Lateral Sclerosis: Use of Digital Technologies - A Precision ALS Project
Amyotrophic Lateral Sclerosis (ALS), the most common form of Motor Neuron Disease (MND), is a neurodegenerative disease. At present there are limited treatment options for this disease which progressively affects physical…
- Trial name
- TechnicALS (NCT06820008)
- Where
- Ireland
- Volunteers
- 60 people
- Sponsor
- University of Dublin, Trinity College
Alzheimer Disease
Alzheimer's National Registry for Treatment and Diagnostics(ALZ-NET)
The Alzheimer's Network for Treatment and Diagnostics (ALZ-NET) will collect longitudinal clinical and safety data for enrolled patients being evaluated for or treated with novel FDA-approved Alzheimer's disease (AD) therapies.
- Trial name
- ALZ-NET (NCT06170268)
- Testing
- Routine Care Documentation
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Alzheimer's Disease and Related Disorders Association, Inc
Alzheimer Disease
Transcranial Magnetic Stimulation (TMS) Treatment for Alzheimer Patients
Transcranial Magnetic Stimulation (TMS) for treatment of Alzheimer disease.
- Trial name
- NCT01334450
- Testing
- TMS , H2-coil
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Hadassah Medical Organization
Tourette Syndrome, Cannabis
The Effect of Medical Cannabis on Tics, Premonitory Urge and Psychiatric Comorbidity in Adults With Tourette Syndrome
Medical cannabis (MC) is a standard treatment in Israel to adults with resistant Gilles de la Tourette syndrome (GTS). While small randomized control trials assessed THC efficacy on tics and premonitory urge, only small…
- Trial name
- NCT05115318
- Testing
- Medical Cannabis
- Where
- Israel
- Volunteers
- 18 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinson's Disease, Parkinson
Comparing Biomarker-Guided DBS Programming With Standard Clinical Monopolar Programming
The goal of this clinical trial is to learn whether an objective, data-guided approach to programming deep brain stimulation (DBS) can improve motor outcomes in people with Parkinson's disease who undergo DBS surgery.
- Conditions
- Parkinson's Disease, Parkinson, Parkinsons Disease (PD), Motor Fluctuations
- Trial name
- NCT07369310
- Testing
- Conventional DBS Programming (Monopolar Review), Objective-Guided DBS Programming (Imaging and Local Field Potential-Based)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Leber's Hereditary Optic Neuropathy
Safety Study of an Adeno-associated Virus Vector for Gene Therapy of Leber's Hereditary Optic Neuropathy
The study is a dose-escalation study, phase 1. The objective of this proposed clinical trial is to evaluate the safety of mitochondrially targeted ND4 gene therapy with the adeno-associated viral vector in appropriate LHON…
- Trial name
- LHON (NCT02161380)
- Testing
- injection of scAAV2-P1ND4v2 1.18x10e9 vg (Low),, injection of scAAV2-P1ND4v2 5.81 X10e9 vg (Med), injection of scAAV2-P1ND4v2 2.4 X10e10vg (High)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Byron Lam
Alzheimer's Disease
Safety, Tolerability and Abeta-specific Antibody Response of Repeated i.m. Injections of Adjuvanted CAD106 in Mild Alzheimer Patients
This study will assess the safety, tolerability and Abeta-specific antibody response of repeated intra-muscular injections of adjuvanted CAD106 in patients with mild Alzheimer's Disease.
- Trial name
- NCT01097096
- Testing
- CAD106, Alum, MF59
- Where
- 31 sites in United States, Belgium and 8 more
- Volunteers
- 177 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson's Disease
Efficacy and Safety of F-18 FPCIT PET in Parkinson's Disease and Essential Tremor Patients
The purpose of this study is to determine whether F-18 FPCIT is effective and safe radiopharmaceutical for the objective diagnosis of Parkinson's disease.
- Trial name
- FPCIT (NCT00468078)
- Testing
- PET/CT, F-18 FPCIT
- Where
- South Korea
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Amyotrophic Lateral Sclerosis (ALS)
Pilot-Study of Thalidomide in Amyotrophic Lateral Sclerosis (ALS)
Neuroinflammation has recently emerged as a significant contributor to motor neuron damage. ALS tissue is characterized by inflammatory changes that are observed in both sporadic and familial ALS and in the ALS superoxide…
- Trial name
- NCT00231140
- Testing
- Thalidomide (drug)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Dementia, Alzheimer Disease
The BRAIN App (Phase 2 SBIR)
There are currently 6.7 million Americans living with dementia and, without significant breakthroughs, this figure will double to 12.7 million by 2050. There are about 46,000 long-term care (LTC) facilities in the U.S.
- Conditions
- Dementia, Alzheimer Disease, Vascular Dementia
- Trial name
- NCT06298474
- Testing
- The BRAIN App
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Hopeful Aging
Alzheimer's Disease
Efficacy and Safety of MK-7622 as Adjunct Therapy in Participants With Alzheimer's Disease (MK-7622-012)
The purpose of this multicenter trial is to assess the efficacy and safety of MK-7622 compared with placebo as adjunctive therapy to acetylcholinesterase inhibitors (AChEIs) for the symptomatic treatment of participants with mild…
- Trial name
- NCT01852110
- Testing
- MK-7622, AChEI
- Volunteers
- 240 people
- Sponsor
- Merck Sharp & Dohme LLC
PD - Parkinson's Disease
Simplified, Scalable, 24-hour Adaptive DBS in Parkinson's Disease
The purpose of this study is to test a new way to treat Parkinson's disease (PD). Subjects will be implanted with deep brain stimulator (DBS) devices and electrodes placed under the scalp.
- Trial name
- Subgaleal aDBS (NCT07398157)
- Testing
- Medtronic Percept Deep Brain Stimulation (cDBS), Medtronic Percept Deep Brain Stimulation (daytime aDBS), Medtronic Percept Deep Brain Stimulation (nighttime aDBS)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Alzheimer Disease
Testing the Effects of a Text Message Caregiver Support Intervention for Latinos
The goal of this randomized clinical trial it to test the efficacy of CuidaTEXT, the first Alzheimer's disease and Related Dementias (ADRD) caregiver support intervention to capitalize on text messaging, among Latinos.
- Trial name
- CuidaTEXT R01 (NCT06728436)
- Testing
- CuidaTEXT
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Parkinson Disease
Vinpocetine in Patients With Parkinsonian Disease
The clinical manifestations of Parkinson's disease (PD), a chronic neurodegenerative condition, include resting tremor, hypokinesia, bradykinesia, stiffness and postural instability.
- Trial name
- NCT07229664
- Testing
- Levodopa Carbidopa, Vinpocetine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Amyotrophic Lateral Sclerosis
EIM Via the Myolex mScan as an ALS Biomarker
Amyotrophic lateral sclerosis (ALS) has been traditionally considered incurable and untreatable. But starting in the 1990s with the introduction of Riluzole, therapies are being discovered and ultimately approved for slowing…
- Trial name
- ElectricALS (NCT06491732)
- Testing
- Electrical Impedance Myography
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- Beth Israel Deaconess Medical Center
Tourette Syndrome
Efficacy of a Therapeutic Combination of Dronabinol and PEA for Tourette Syndrome
This is an investigator-initiated proof of concept study with the purpose to examine the safety, tolerability and feasibility of Dronabinol (synthetic Δ9-THC) and PEA for the treatment of adults with Tourette syndrome.
- Trial name
- NCT03066193
- Testing
- Dronabinol and Palmitoylethanolamide
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Yale University
Spinal Muscular Atrophy
A Registered Cohort Study on SMA
Spinal muscular atrophy (SMA) is an autosomal recessive disease that causes progressive muscle wasting and weakness due to loss of motor neurons in the spinal cord.
- Trial name
- NCT04010604
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Wan-Jin Chen
Cancer, Breast, Alzheimer Disease
Decisions About Cancer Screening in Alzheimer's Disease
The Decisions about Cancer screening in Alzheimer's Disease (DECAD) study tests if an evidence-based decision aid for dementia caregivers can support decision-making about mammography and improve the quality of medical…
- Trial name
- DECAD (NCT03282097)
- Testing
- DECAD decision aid, Home safety guide
- Where
- 5 sites in United States
- Volunteers
- 442 people
- Sponsor
- Indiana University
Dementia, Alzheimer Type
Aripiprazole in the Treatment of Patients With Psychosis Associated With Dementia of Alzheimer's Type
The primary objective of the study is to compare the efficacy of aripiprazole with placebo in patients with psychosis associated with Alzheimer's dementia.
- Trial name
- NCT01438060
- Testing
- Aripiprazole (BMS-337039)
- Volunteers
- 232 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.