Clinical trials: Evidence-Based Medicine
Dyslipidemia, Diabetes
Meta-analyses of the Effect of Important Food Sources of Sugars on Cardiometabolic Risk Factors
Fructose-containing sugars have been implicated in the epidemics of obesity, diabetes and related cardiometabolic disorders. This view is supported by lower quality evidence from ecological observations, animal models, and select…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT02716870
- Testing
- Fructose-containing Sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Breast Cancer
Mastectomy Reconstruction Outcomes Consortium (MROC) Study
The MROC Study seeks to evaluate and compare from the patient's point of view the leading options for breast reconstruction after mastectomy.
- Trial name
- MROC (NCT01723423)
- Where
- 11 sites in United States, Canada
- Volunteers
- 4,436 people
- Sponsor
- University of Michigan
Cardiovascular Diseases
Nudges for Statin Prescribing in Primary Care
The objective of the study is to evaluate the effect of nudges to clinicians, patients, or both to initiate statin prescriptions for patients that meet national guidelines.
- Trial name
- NCT04307472
- Testing
- Clinician Nudge, Patient Nudge
- Where
- United States
- Volunteers
- 4,131 people
- Sponsor
- University of Pennsylvania
Acute Renal Injury
Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans
Implementation of an evidence-based and best practices acute RRT pathway aiming to decrease acute RRT program and healthcare systems costs while improving important patient-reported outcomes.
- Trial name
- NCT05186636
- Testing
- KPI reports, Prescriber reports
- Where
- 15 sites in Canada
- Volunteers
- 9,348 people
- Sponsor
- University of Alberta
Coronary Heart Disease, Myocardial Infarction
Monitoring and Adjustment of Medication Therapy for Patients With Heart Disease
Existing trials for the patient with coronary heart disease evaluate the interdisciplinary team dynamic where pharmacists (pharmacotherapists) provide therapeutic recommendations in the inpatient environment.
- Trial name
- MUMPS (NCT01427218)
- Testing
- Titration of medications, Lifestyle Counseling, Medication Counseling
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Middle Tennessee Research Institute
Hypertension, Diabetes Mellitus
Clinical Decision Support for Medication Management and Adherence
This three-year, grant funded project will be conducted by the Division of Clinical Informatics in the Department of Community and Family Medicine at Duke University Medical Center.
- Conditions
- Hypertension, Diabetes Mellitus, Stroke, Myocardial Ischemia
- Trial name
- NCT00979225
- Testing
- Medication Management report, Care manager email notices
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Duke University
Smoking Cessation
ISTAPS: A Stepped Primary Care Smoking Cessation Intervention
Primary care centers can play a very important role in helping people to stop smoking. There is a large body of research on the effectiveness of specific interventions especially addressed to people who want to stop smoking.
- Trial name
- NCT00125905
- Testing
- Advice, Motivational Interviewing, Nicotine Gum and Patch
- Where
- Spain
- Volunteers
- 3,012 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Diabetes, Prediabetes
Meta-analyses of the Effect of Dietary Pulses on Acute Postprandial Metabolic Control
Dietary pulses (beans, peas, chickpeas, and lentils), more commonly known as "legumes", are generally recognized as healthy components of the diet.
- Conditions
- Diabetes, Prediabetes, Dysglycemia, Overweight
- Trial name
- NCT01605422
- Testing
- Dietary pulses
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Depression, Anxiety
More Individualized Care: Assessment and Recovery Through Engagement
The MI-CARE trial tests 12 months of telephone-based nurse care management for patients with depressive symptoms who take or have taken opioids at some time.
- Conditions
- Depression, Anxiety, Opioid-Related Disorders, Pain, Chronic
- Trial name
- MI-CARE (NCT05122676)
- Testing
- More Individualized Care: Assessment and Recovery through Engagement (MI-CARE)
- Where
- 2 sites in United States
- Volunteers
- 805 people
- Sponsor
- Kaiser Permanente
Adverse Drug Reactions, Clinical Decision Support
Multi-Agent Collaborative ADR Prediction With Human-Machine Decision Comparison
This study develops a multi-agent collaborative prediction model to forecast adverse drug reactions using real-world clinical medical records.
- Trial name
- NCT07808866
- Testing
- Retrospective medical record data analysis only, no clinical intervention
- Where
- 2 sites in China
- Volunteers
- 20,000 people
- Sponsor
- Peking University Third Hospital
Aging, Mild Cognitive Impairment
My Healthy Brain: Preserving and Promoting Brain Health Through Evidence-based Practices
The objective of this trial is to demonstrate early proof-of-concept for My Healthy Brain, an 8-week group program that directly targets multiple lifestyle factors associated with brain health and prevention of cognitive decline.
- Conditions
- Aging, Mild Cognitive Impairment, Dementia, Old Age; Dementia
- Trial name
- NCT04537728
- Testing
- My Healthy Brain Version 2
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Hypertension
VISN Collaborative for Improving Hypertension Management With ATHENA-HTN
This project is a VA HSR\&D-funded Quality Enhancement Research Initiative (QUERI) project to translate into practice evidence about clinical management of primary hypertension.
- Trial name
- HTN (NCT00374452)
- Testing
- ATHENA-CDS-HTN plus Guideline Link, Guideline Link Only
- Where
- 7 sites in United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Diabetic Nephropathy
Naoxintong Capsule for Diabetic Nephropathy With Dampness Retention Pattern: A Multicenter, Randomized, Double-Blind, Placebo-Controlled TrialAcronymNXT-DKD
Diabetic nephropathy (DN) is a leading cause of end-stage kidney disease worldwide and is associated with a high risk of cardiovascular events and mortality.
- Trial name
- NXT-DKD (NCT07698223)
- Testing
- Naoxintong Capsule
- Where
- 8 sites in China
- Volunteers
- 410 people
- Sponsor
- Chen Xiangmei
Health Knowledge Attitudes and Practice
Evidence Based Medicine in General Practice
Evidence-based medicine (EBM) is the basis of work for physicians- practitioners in all specialties, including family medicine. Various issues in diagnosis, treatment and prognosis appear in daily work with patients and a…
- Trial name
- EBMINGP (NCT01801683)
- Testing
- Intervention-using PEARLS
- Volunteers
- 98 people
- Sponsor
- University of Split
Venous Thromboembolism, Bleeding
Avoiding Risks of Thrombosis and Bleeding in Surgery (ARTS) Trial
Avoiding Risks of Thrombosis and bleeding in Surgery (ARTS) trial is a pragmatic, international, multicenter, randomized controlled open label trial comparing a direct oral anticoagulant (DOAC) - oral factor Xa inhibitor apixaban…
- Trial name
- ARTS (NCT06523959)
- Testing
- Apixaban 2.5 MG
- Where
- Finland
- Volunteers
- 5,436 people
- Sponsor
- Clinical Urology and Epidemiology Working Group
Nursing, Evidence-Based Nursing
The Effect of HBM-Based Education on Nursing Students
The purpose of the study is to investigate the effect of HBM-based education on CAM knowledge, attitudes, and health beliefs related to medication use among nursing students through a randomized controlled trial.
- Trial name
- HBM (NCT06262698)
- Testing
- Experiment group, Pre-post test
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kafkas University
Attention Deficit-hyperactivity Disorder
Assesment of TDApp1 an eHelath Tool to Make Therapeutic Recommendations for Patients With ADHD
This is a 3-week open label, one group study to determine the agreement between the pharmacological treatment recommended by TDApp1 and the interventions recommended by relevant clinical practice guidelines.
- Trial name
- NCT04228094
- Testing
- TDApp1: an eHealth intervention
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Universitat de Girona
Heart Diseases
A Partnership to Translate an Evidence-based Intervention (Take Heart) for Vulnerable Older Adults With Heart Disease
To evaluate the effectiveness of Take Heart, a behavioral/educational program for adults age 50+ with heart disease, or with at least two risk factors for heart disease, that helps them to better manage their health condition(s).
- Trial name
- NCT02950818
- Testing
- Take Heart
- Where
- United States
- Volunteers
- 453 people
- Sponsor
- University of Michigan
Sexual Behavior, Sexually Transmitted Disease (STD)
Cultural Adaptation, Validation, and Evaluation of the Programme for Promotion of Healthy Affective-Sexual Behaviours in Adolescents (IYG)
The investigators are writing to inform participants about a study being carried out by a research group from the University of Granada and the University of Seville, in which the participant's son/daughter is invited to…
- Conditions
- Sexual Behavior, Sexually Transmitted Disease (STD), Condom Use, Adolescent Health
- Trial name
- IYG (NCT07208045)
- Testing
- Es tu juego: decide bien (IYG)
- Where
- Spain
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Seville
Health Services Misuse, Physician's Practice Patterns
Primary Care Clinician Commitments to Choosing Wisely®
This pragmatic trial examines the uptake and effects of primary care clinician commitments to follow 3 Choosing Wisely® recommendations.
- Conditions
- Health Services Misuse, Physician's Practice Patterns, Guideline Adherence, Unnecessary Procedures
- Trial name
- NCT02247050
- Testing
- Commitment invitation
- Where
- 6 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Michigan