Clinical trials: OA
Osteoarthritis (OA) of the Knee
Optimization of Obesity for Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist
Studies have shown that obese patients undergoing total knee replacement (TKR) surgery face a higher risk of perioperative issues such as increased use of pain medication, surgical site infections, and the need for revision…
- Trial name
- NPO-OOPS-TKR (NCT06807970)
- Testing
- Glucagon-like peptide-1 receptor agonists (GLP 1 RA), Control (Standard treatment)
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- The University of Hong Kong
Osteoarthritis (OA) of the Knee
Total Osteo-Cartilage Replacement for the Treatment of Osteoarthritis of Knee
Young patients who require total knee arthroplasty with metallic and plastic implants will undergo femoral condyle cartilage and top of the tibia with meniscus replacement.
- Trial name
- NCT07769632
- Testing
- Total osteo-cartilage replacement of the distal femur and proximal tibia, including medial and lateral meniscus., allogenic bone and cartilage graft
- Where
- Bahrain
- Volunteers
- 10 people
- Sponsor
- AlSalam Hospital
Osteoarthritis (OA) of the Knee
Kinesio Taping After Platelet-Rich Plasma Treatment in Individuals With Knee Osteoarthritis
This randomized controlled study evaluated whether kinesio taping provided additional benefits compared with sham taping in women with knee osteoarthritis who had received platelet-rich plasma (PRP) treatment as part of routine…
- Trial name
- NCT07773324
- Testing
- Kinesio Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Agri Ibrahim Cecen University
Osteoarthritis (OA) of the Knee
Anti-Diabetic Drug, Exercise and Healthy Diet for Knee Osteoarthritis With Overweight/Obesity
Obesity is associated with increased pain with knee osteoarthritis and increase progression of knee osteoarthritis while weight loss intervention has been shown to reduce pain and requirement of total knee replacement.
- Trial name
- ADDED (NCT07065591)
- Testing
- Metformin
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Osteoarthritis (OA) of the Knee
Cohort of Lower-Extremity Sports Injuries and Degeneration(Yongjiang Cohort)
This is an observational cohort study conducted at Ningbo No. 2 Hospital. The study will include patients with knee-related sports injuries or degenerative knee conditions who receive routine clinical care.
- Trial name
- NCT07592871
- Testing
- Routine Clinical Care
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ningbo No.2 Hospital
Osteoarthritis (OA) of the Knee, Knee Pain Arthritis
Imageless Navigation Versus Image-Based Navigation in Robotic-Assisted Total Knee Arthroplasty for Knee Osteoarthritis
The goal of this clinical trial is to learn if imageless navigation is not inferior to image-based navigation in robotic-assisted total knee arthroplasty (RA-TKA) for treating patients with knee osteoarthritis.
- Conditions
- Osteoarthritis (OA) of the Knee, Knee Pain Arthritis, Total Knee Arthroplasty (TKA), Robotic Assisted Arthroplasty
- Trial name
- NCT07522489
- Testing
- Imageless Robotic-Assisted Total Knee Arthroplasty, Image-based Robotic-Assisted Total Knee Arthroplasty
- Where
- Poland
- Volunteers
- 146 people
- Sponsor
- Medical University of Warsaw
Knee Osteoarthritis (Knee OA)
Evaluation of a Preoperative Education in Total Knee Arthroplasty
The benefit of preoperative rehabilitation treatment combining physiotherapy and targeted education for patient undergoing Total Knee replacement (TKR) is now well known.
- Trial name
- EPOP (NCT01747759)
- Testing
- Kruskal-Wallis and qualitative parameters
- Where
- France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Clermont-Ferrand
Osteoarthritis, Osteoarthritis (OA) of the Knee
Effect of Autologous Ear Cartilage Micrografting in Knee Osteoarthritis
The goal of this clinical trial is to learn if a single injection of autologous cartilage micrografts suspension, obtained through processing with a specialized technology patient's own small piece of ear cartilage, can improve…
- Conditions
- Osteoarthritis, Osteoarthritis (OA) of the Knee, Moderate Osteoarthritis
- Trial name
- EAR2KNEE (NCT07755579)
- Testing
- Mytocel MSK - Autologous Ear Cartilage Micrografting
- Where
- Hungary
- Volunteers
- 33 people
- Sponsor
- Regenera Activa Worldwide S.L.
Osteoarthritis (OA) of the Knee
Comparison of Postoperative Functional Outcomes Between Subvastus and Medial Parapatellar Approach in Total Knee Arthroplasty
This study aims to compare the effects of the medial parapatellar approach (MP) and the subvastus approach (SV) on postoperative clinical function in total knee arthroplasty (TKA).
- Trial name
- NCT07742696
- Testing
- subvastus, medial parapatellar
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Peking University Third Hospital
Osteoarthritis (OA) of the Knee, Pain
ASKC200 for Knee Osteoarthritis Pain
This is a Phase II clinical trial designed to evaluate the efficacy and safety of ASKC200 Lotion in patients with knee osteoarthritis (KOA) pain.
- Trial name
- ASKC200 (NCT07742852)
- Testing
- 5% ASKC200, 1% Diclofenac Diethylamine Emulgel, 1% ASKC200
- Where
- China
- Volunteers
- 175 people
- Sponsor
- Jiangsu Aosaikang Pharmaceutical Co., Ltd.
Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR)
The goal of this clinical trial is to see if people with knee osteoarthritis would be willing to comply and adhere to incorporating Recombinant Human Growth Hormone (rHGH), specifically Saizen Somatropin solution, into their…
- Trial name
- KORR (NCT07036003)
- Testing
- Somatropin (recombinant human growth hormone)
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Dr. David Wasserstein
Total Knee Anthroplasty, Osteoarthritis(Primary)
COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA.
- Conditions
- Total Knee Anthroplasty, Osteoarthritis(Primary), Osteoarthritis (OA) of the Knee, Bilateral Knee Osteoarthritis
- Trial name
- COSTI (NCT06809998)
- Testing
- Corticosteroid Injection - 80mg methylprednisolone (total volume 2ml) with 6 mL of 1% Bupivacaine without epinephrine (Total Volume 8 mL)., Band-Aid
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Spinal Cord Injuries (SCI), Osteoarthritis (OA)
Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Spinal Cord Injury
Spinal cord injury patients often present with musculoskeletal comorbidities, including osteoarthritis. Early detection of cartilage damage is important for preventing osteoarthritis progression.
- Trial name
- NCT07293949
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Knee Osteoarthritis (Knee OA), Knee Arthritis, Osteoarthritis
Effects of Pressure Biofeedback Training Versus Bolster Foam Roll Training for Pain, Muscles Activation, and Quality of Life Among Knee Osteoarthritis Patients
The current study will be a single-blinded, two-arm parallel group randomized clinical trial involving 48 participants. The trial will compare Pressure Biofeedback training with Bolster Foam Roll training.
- Trial name
- NCT07731737
- Testing
- pressure Biofeedback Training, Bolster Foam Roll Training
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Osteoarthritis (OA) of the Knee
Web-Based Conversational Assistant After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is one of the most frequently performed elective orthopaedic procedures. Following hospital discharge, patients must manage pain, wound care and home rehabilitation with limited professional support.
- Trial name
- CARE-TKA (NCT07731815)
- Testing
- Web-based conversational postoperative assistant
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Wojciech Sroga
Knee Osteoarthritis (OA), Total Knee Arthroplasty (TKA)
Manual Traction and Rehabilitation After Knee Replacement Surgery
The goal of this clinical trial is to determine whether the addition of manual traction to a standard rehabilitation protocol improves early recovery after primary total knee arthroplasty (TKA) in women aged 50-75 years with knee…
- Trial name
- SMART-TKA (NCT07722559)
- Testing
- Manual Tibiofemoral Traction
- Where
- Kosovo
- Volunteers
- 48 people
- Sponsor
- Alma Mater Europaea - Slovenia
OA Knee, OA Knee Pain
Comparison of Medial Knee Pain Between Patients With and Without Preoperative Tibia Vara Underging Mobile-bearing Unicompartmental Knee Arthroplasty
to compared VAS for medial knee pain between oa knee with or without tibia vara following mobile bearing UKA
- Conditions
- OA Knee, OA Knee Pain, Osteoarthritis
- Trial name
- bow leg (NCT07720024)
- Testing
- mobile bearing UKA
- Where
- Thailand
- Volunteers
- 150 people
- Sponsor
- Thammasat University
Knee Osteoarthritis (OA)
Instrument-Assisted Soft Tissue Mobilization as an Adjunct to Therapeutic Exercises in Individuals With Knee Osteoarthritis
To determine the efficacy of IASTM as an adjunct to therapeutic exercises on pain, range of motion, and functional performance in individuals with knee OA.
- Trial name
- NCT07710209
- Testing
- IATSM, Therapeutic Exercise
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Foundation of Medical Research and Laboratories, Pakistan
Knee Osteoarthritis (OA)
Dry Needling and Kinesio Taping as Adjuncts to Strength Training on Pain, Functional Mobility, and Quality of Life in Patients With Knee Osteoarthritis
To compare the effects of dry needling and Kinesio taping, each combined with strength training, on pain, functional mobility, and quality of life in patients with knee OA.
- Trial name
- NCT07710235
- Testing
- Dry Needling Combined with Strength Training, Kinesio Taping Combined with Strength Training, Strength Training
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Foundation of Medical Research and Laboratories, Pakistan
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain
Knee osteoarthritis (KOA) is a common joint disease that causes chronic pain and limits daily activities. Current treatments, such as painkillers or surgery, have limitations like side effects or high costs.
- Trial name
- NCT07698418
- Testing
- Inspiratory muscle training
- Volunteers
- 80 people
- Sponsor
- The Hong Kong Polytechnic University