Clinical trials: Peripheral Blood Flow
Healthy, Healthy Participants
Acute Effects of Structured Exercise and Static Stretching on Vascular Function, Neuromuscular Performance, and Metabolic Regulation in Adults
This experimental study investigates the acute cardiovascular and vascular responses to a single session of resistance training, with and without additional static stretching, compared with a resting control condition.
- Conditions
- Healthy, Healthy Participants, Healthy Subjects (HS), Resistance Training Adaptation
- Trial name
- NCT07364149
- Testing
- Resistance Training, Resistance training + Static Stretching
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Glaucoma
Ocular Blood Flow Imaging for Glaucoma Assessment
The goal of this clinical trial is to investigate the use of an FDA-cleared retinal blood flow imaging instrument called the XyCAM RI and XyCAM FC (Vasoptic Medical, Inc., Columbia, MD) in glaucoma management.
- Trial name
- NCT05726058
- Testing
- XyCAM with oxygen
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Respiratory Amplitude, Portal Blood Flow
Variations of Portal Flow During the Respiratory Cycle in Healthy Volunteers
The analysis of portal vein blood flow is important when assessing the severity and progression of liver disease. It is important to understand normal liver regulation in order to appreciate the evaluation of the effect of…
- Conditions
- Respiratory Amplitude, Portal Blood Flow, MRI, Echo Planar Imaging
- Trial name
- RESPIFLUX (NCT04782531)
- Testing
- peripheral ECG, Standard MRI
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Healthy Volunteers, Low Back Pain
Effects of Blood Flow Restriction Exercises on Lumbar Muscle Endurance and Balance in Healthy Young Adults
This study aims to examine the effects of blood flow restriction (BFR) exercises on back muscle endurance and balance in healthy young adults.
- Conditions
- Healthy Volunteers, Low Back Pain, Postural Balance, Muscle Fatigue
- Trial name
- BFR-LUMBEX (NCT07182812)
- Testing
- Blood Flow Restriction Sit-to-Stand Exercise, Sit-to-Stand Exercise without Blood Flow Restriction
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mehmet Akif Guler
Blood Vessel Disease, Muscle Edema
The Influences of Single Chamber vs. Multi-chamber Blood Flow Restriction Cuffs
The purpose of this study is to investigate the use of single (SC) and multi-chamber (MC) blood flow restriction (BFR) cuff exercise on indices of arterial stiffness, muscle morphology, and participant perception.
- Trial name
- NCT06276673
- Testing
- Delfi
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Salisbury University
Blood Flow in Healthy Volunteers
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia
The endogenous nucleoside adenosine can induce various cardiovascular and neurohumoral effects by stimulation of specific adenosine receptors.
- Trial name
- NCT00253929
- Testing
- Intra-arterial infusion of adenosine, intra-arterial infusion of caffeine, intra-arterial infusion of acetylcholine
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ischemic Preconditioning
Conditioning Based Intervention Strategies
The overall objective of this study is to uncover and utilize the mechanisms behind the activation of endogenous organ protection by remote ischemic conditioning (RIC), high intensity traditional resistance training (TRT) and low…
- Trial name
- ConBIS (NCT03380663)
- Testing
- Remote Ischemic Conditioning (RIC)
- Where
- Denmark
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy
Role of Endothelin-1 in Optic Nerve Head Blood Flow Regulation During Isometric Exercise in Healthy Humans
Autoregulation is defined as the ability of a vascular bed to adapt its vascular resistance to changes in perfusion pressure. In the eye, several studies have reported that retinal blood flow is autoregulated over a wide range of…
- Trial name
- NCT00915070
- Testing
- BQ-123, Physiological saline solution, Laser Doppler Flowmetry
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Sarcopenia in Elderly, Muscle Atrophy
Effects of Cyclical Blood Flow Restriction Exercise on Muscle Hypertrophy and Capillaries in Older Adults
The purpose of this study was to learn if low-load resistance exercise combined with cyclical blood flow restriction (BFR) could improve small blood vessel structure and muscle size in older adults.
- Conditions
- Sarcopenia in Elderly, Muscle Atrophy, Aging
- Trial name
- NCT07689487
- Testing
- Blood Flow Restriction (BFR), Conventional Low-Load Resistance Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Healthy Male Subjects
Effect of Sodium Nitroprusside on Cerebral Blood Flow
The brain has a high energy demand and requires continuous blood flow. The blood flow to the brain appears to be unaffected by small changes in blood pressure, but brain blood flow may be reduced by a large reduction in blood…
- Trial name
- NCT03317652
- Testing
- Hyperventilation, 6% CO2 breathing, Infusion of sodium nitroprusside
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy Subjects, Sports Level 1
Effect of Blood Flow Restriction Training to Muscle Strength, Dynamic Stability, and ACL Injury Prevention
The goal of this randomized clinical trial study is to compare low-load blood flow restriction (LL-BFRt), sham LL-BFRt, and high-load eccentric training (HL-Et) in healthy level 1 sportsman.
- Trial name
- NCT05951036
- Testing
- Low-load Blood Flow Restriction training, High-load Eccentric training
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Udayana University
Headache
Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow
To investigate headache score and accompanying symptoms during and after infusion of carbachol.
- Trial name
- NCT00357864
- Testing
- carbachol
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Distal Radius Fracture
BFR Therapy Following DRF
This study's goal is to evaluate whether blood flow restriction supplemented therapy is a superior therapy compared to traditional standard of care while recovering from a surgery that repairs distal radius fractures.
- Trial name
- NCT05396521
- Testing
- Blood Flow Restriction, Standard of Care Physical Therapy
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Cerebral Blood Flow, Cerebral Perfusion Pressure
Continous Assessment of Cerebral Autoregulation With Near-infrared Spectroscopy
Cerebral autoregulation can be explained by a tight coupling between oxygen supply and demand of the brain, and is essential to maintain a constant cerebral blood flow (CBF) in the context of changes in cerebral perfusion…
- Trial name
- NCT02959008
- Testing
- measure TOI and BP
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yu Liyun
Coronary Heart Disease
Cadmium-zinc-telluride (CZT) Imaging of Myocardial Blood Flow (MBF) (SPECT MBF)
This study is being done to compare the blood flow measurements obtained with the SPECT and PET imaging scans. Measurements such as myocardial blood flow (MBF) and myocardial flow reserve (MFR) are analyzed on PET scans.
- Trial name
- SPECTMBF (NCT02280941)
- Testing
- single photon emission computed tomography
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Type 2 Diabetes, Obesity
Splanchnic Blood Redistribution After Incretin Hormone Infusion and Obesity Surgery
Obesity is a worldwide problem and leads to multiple metabolic and endocrinological problems. Bariatric surgeries are a growing field as a treatment choice for morbid obesity (BMI > 35 kg/m2).
- Trial name
- GIP-PET (NCT01880827)
- Testing
- Roux-en-Y, GIP-infusion, GLP-1
- Where
- Finland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Cardiovascular Diseases
Effects of Oral Antioxidant Cocktail in Cardiovascular Disease Patients
Title: Effects of oral antioxidant cocktail on vascular function and muscle function in cardiovascular disease patients Cardiovascular disease (CVD) generally refers to various conditions involving narrowed or blocked…
- Trial name
- NCT03629613
- Testing
- Oral antioxidant cocktail, Baseline
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Functional Magnetic Resonance Imaging
A Study of Two Methodologies for Measuring Blood Flow in the Brain in Response to Non-Drug Stimuli (P08085/MK-0000-180)
This study will identify a dose of ferumoxytol that can reliably detect changes in blood flow/volume in response to non-drug stimuli.
- Trial name
- NCT01244282
- Testing
- fMRI with sensory stimulation
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Coronary Artery Disease
Development and Translation of Generator-Produced PET Tracer for Myocardial Perfusion Imaging-Dosimetry Group
This study is a single center, early phase 1 clinical imaging study designed to assess the dosimetry of 68Ga-Galmydar for PET/CT imaging.
- Trial name
- GALMYDAR (NCT05280782)
- Testing
- Ga-68 Galmydar
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine