Clinical trials: Prognosis
Heart Failure, Diastolic, Multicenter Study
Diagnosis and OutcoMes evaluAtIoN of Multicenter Patients With HFpEF Using Multimodality Imaging
The incidence of Heart failure with preserved ejection fraction (HFpEF) in Heart failure patients increases rapidly. However, the current clinical awareness is insufficient, and the cardiac structural and functional injury are…
- Trial name
- NCT04602338
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Ischemic Heart Disease, Prostate Adenocarcinoma
Ischemic Heart Disease in Male With Prostate Adenocarcinoma
The purpose of the study: to increase the efficiency of diagnosis, treatment and prediction of the course of coronary heart disease in patients with adenocarcinoma of the prostate gland, depending on the hormonal status by…
- Trial name
- NCT03474835
- Testing
- ISCHEMIC HEART DISEASE diagnostic
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dnipropetrovsk State Medical Academy
Hypoparathyroidism
Hypoparathyroidism in Denmark
The purpose of this study is to identify the number of persons in Denmark with the diagnose hypoparathyroidism, autosomal dominant hypocalcaemia or pseudohypoparathyroidism.
- Trial name
- HypoPT (NCT01498341)
- Where
- Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Rh Disease
Circulating microRNAs as Novel Prognosis Biomarkers for Rheumatoid Arthritis
The correlation of circulating serum miR-125ba and miR-146a expression and clinical response to green tea therapy were analysed in RA patients.Clinical response to green tea therapy for 24 weeks was calculated from DAS28 scores.
- Trial name
- NCT03719469
- Testing
- Green tea group
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- King Saud University
Terminal Illness
ADJUST: A Study on MDT Prognostication
This study investigates how clinicians form intuitive judgements about the prognoses of palliative care patients after receiving advice perceived as coming from either a team member or an algorithm.
- Trial name
- ADJUST (NCT04568629)
- Testing
- Advice from the PiPS-B14 prognostic tool, Advice from another clinician
- Where
- United Kingdom
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- University College, London
Panic Disorder
Investigations of Factors Associated With Treatment Response and Prognosis in Anxiety Disorders
The purpose of this study is to build a comprehensive brain and behavioral dataset on anxiety disorders and identify clinical factors related to treatment response and prognosis in patients with anxiety disorders.
- Trial name
- IRPA (NCT06773585)
- Testing
- Psychiatric scale assessments, VR-Based Behavioral Assessment, Brain MRI
- Where
- South Korea
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Kangbuk Samsung Hospital
Cardiovascular Diseases, Stroke
Prediction of Primary Cardiovascular Events Using the Multimarker Approach
The study of biochemical risk factors for cardiovascular diseases is important not only for analysis, but also for preventive measures, given that changes in the level of biomarkers can be detected before the first clinical…
- Conditions
- Cardiovascular Diseases, Stroke, Myocardial Infarction, Death
- Trial name
- NCT05704569
- Testing
- measurement of multiple biomarkers
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Karaganda Medical University
Coronary Artery Disease
The Association Between Very Small Embryonic-like Stem Cells and the Prognosis of Coronary Artery Disease Patients
Hypothesis: Peripheral blood Very Small Embryonic-like Stem Cells (VSELs) are different in coronary artery disease (CAD) patients from those without CAD, which might account for the benefits of Atorvastatin in CAD patients.
- Trial name
- VSEL-CAD (NCT01633359)
- Testing
- Intensive statin, Routine statin
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ji Huang
Stroke, Ischemic, Prolidase Deficiency
Prolidase Enzyme Activity in Stroke Patients
Stroke is a major cerebrovascular disease that causes significant burdens for human health and life, including high morbidity, mortality, and disability.
- Trial name
- NCT03334968
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Breast Cancer
Plant-derived Nutrients in the Prevention and Prognosis of Breast Cancer in Women.
This study evaluates the impact of plant-derived nutritional interventions on inflammation, immune function-related indicators, and quality of life in healthy women and breast cancer patients based on real-world data, providing…
- Trial name
- Plant (NCT07868159)
- Testing
- Curcumin
- Where
- China
- Volunteers
- 639 people, healthy volunteers welcome
- Sponsor
- Keda Yu
Depressive Symptoms, Hypomania Nos Single Episode or Unspecified
A Study of Aerobic Exercise for Adolescents With Subthreshold Mood Syndromes
This study will investigate the effects of aerobic exercise on mental states, cognition, and long-term outcomes in adolescents with subthreshold depressive and/or hypomanic syndromes and in non-clinical school children
- Trial name
- NCT03300778
- Testing
- aerobic exercise
- Where
- China
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Brain Injury, Coma, Cardiac Arrest (CA)
Prediction for Coma Recovery With Comaweb
The general objective of the comaScore project is to provide an external validation of the accuracy of the comaScore, a score derived from magnetic resonance imaging (MRI), to predict 1 year outcome of patients unresponsive to…
- Conditions
- Brain Injury, Coma, Cardiac Arrest (CA), Traumatic Brain Injury (TBI), Aneurysmal Subarachnoid Hemorrhages (aSAH)
- Trial name
- COMASCORE (NCT03874208)
- Testing
- MRI sequence, MRI
- Where
- France
- Volunteers
- 611 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia (PE), Hypertensive Disorder of Pregnancy
Endothelial Dysfunction for Prognosis In Patients With preeClampSia
Preeclampsia is a pregnancy-specific hypertensive disorder and can progress rapidly to severe adverse outcomes affecting both the mother and the fetus.
- Trial name
- EPICS (NCT06912477)
- Testing
- Hyperspectral imaging, Further markers of endothelial dysfunction
- Where
- Germany
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
GVHD, Bone Marrow Transplant Failure
α1-antitrypsin (AAT) Levels and Functions in Allogeneic Bone Marrow Transplantation and Throughout Progression Into GVHD
Create a personalized time and context curve of patient circulating α1-antitrypsin (AAT) levels and functions before hematopoietic stem cell transplantation and throughout progression into GVHD. PRIMARY ENDPOINT 1.
- Conditions
- GVHD, Bone Marrow Transplant Failure, Alpha 1-Antitrypsin
- Trial name
- AATGVHD-MARK (NCT03188601)
- Where
- 4 sites in Israel
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Sepsis
Dendritic Cells-Derived Exosomes in Human Sepsis
The amount of peripheral blood exosomes has been confirmed to change in the endotoxin-induced infection. The primary objectives of this study are to compare the changes of peripheral blood dendritic cell-derived exosomes in the…
- Trial name
- NCT02957279
- Testing
- Antibiotics
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Tau Distributions in Patients With Tauopathy Using APN-1607 PET Scan
Establishing 18F PMPBB3 (APN 1607) PET Imaging Markers for Diagnosis of Tauopathy Parkinsonism Syndromes
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The diagnosis of PD is primarily based on clinical presentations while the pathology stage of a-synuclein containing Lewy body deposition has already…
- Trial name
- NCT04557865
- Testing
- 18F-PMPBB3 (APN-1607) PET imaging
- Where
- Taiwan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Post-stroke Dementia, Vascular Mild Cognitive Impairment
The Influence of Sequential Tau Protein and Amyloid Plaque Imaging Changes on Stroke Prognosis and Cognitive Outcome
Amyloid plaques and tau protein are the landmarks of neurodegeneration in Alzheimer's disease (AD). On the other hand, it is reported that cerebral ischemia may induce amyloid plaques and tau protein accumulation.
- Trial name
- NCT04572477
- Testing
- [18F]THK-5351, [18F]AV-45
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Phaeohyphomycosis
Efficacy of PD-1 Monoclonal Antibody in the Treatment of Phaeohyphomycosis
The main objective was to evaluate the clinical efficacy of PD-1 inhibitor (PD-1 monoclonal antibody) in the treatment of skin and subcutaneous mucocytosis infection, including the comparison of immune cell groups before and…
- Trial name
- NCT06796231
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Panvascular Diseases, Cardiovascular Diseases
Diagnosis, Prognosis, and Mechanisms in Panvascular Disease
This study aims to establish a standardized cohort for panvascular diseases, encompassing biological materials such as DNA samples, along with extensive patient medical records and follow-up information.
- Trial name
- PRO-PVD (NCT07151183)
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Jinwei Tian
Cervical Intraepithelial Neoplasia Grade 2, DNA Methylation
The Role of FAM19A4 and Hsa-mir-124 Methylation in Predicting Prognosis of Untreated Cervical Intraepithelial Neoplasia 2 (CIN 2)
High-risk precancerous cervical lesions are divided into stage 2 and 3 cervical intraepithelial neoplasia (CIN 2 and 3). CIN 3 represents a direct pre-stage of invasive cancer, has a high rate of progression and a high degree of…
- Trial name
- NCT05624827
- Testing
- Testing DNA methylation test for predicting prognosis of untreated CIN 2
- Where
- Slovenia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor