Clinical trials: Satiety Hormones
Diabetes Mellitus, Diabetes Mellitus, Type 2
The Effect of GLP-1 Receptor Activation on Central Reward and Satiety in Obesity and Diabetes
Glucagon-like peptide 1 (GLP-1) based therapies, such as exenatide, are already successfully employed in the treatment of Type 2 Diabetes (T2DM).
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 2, Obesity
- Trial name
- Braini-Ex (NCT01281228)
- Testing
- exenatide, exenatide + exendin (9-39)
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Appetite and General Nutritional Disorders
Effects of Positive Energy Balance and Exercise on Appetite Hormones in Sedentary Men and Women
The purpose of this research study is to examine the effects of overfeeding and exercise on blood levels of hormones associated with regulating appetite, also thought of as feelings of hunger and satiety (fullness).
- Trial name
- NCT01354600
- Testing
- Exercise or Sedentary
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Protein Metabolism
Effects of Protein Type and Mineral Form on Amino Acid Availability
To compare postprandial plasma amino acid availability, expressed as incremental area under the curve (iAUC), over a 6 hour period following ingestion of 25 g of different protein isolates in healthy, young adults.
- Trial name
- ProMin (NCT07677098)
- Testing
- Protein beverage
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Energy Intake, Gastrointestinal Hormones
Effects of Oral Xylitol on Subsequent Energy Intake
The aim of this project is to investigate the effect of xylitol (given as pre-load), compared to sucrose, Ace-K, and water on energy intake during a subsequent ad libitum test meal in healthy participants.
- Conditions
- Energy Intake, Gastrointestinal Hormones, Glycemic Control, Appetite
- Trial name
- NCT05671965
- Testing
- Xylitol, Sucrose, Acesulfame Potassium
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy
Effect of Herbs and Spices on Metabolic Regulation and Appetite in Healthy Subjects
The purpose of the study is to investigate how herbs and spices affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective appetite…
- Trial name
- AFC-SPICES (NCT02035241)
- Testing
- Spices 1, Spices 2, Spices 3
- Where
- Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lund University
Obesity
Full4Health: Understanding Food-gut-brain Axis Across the Lifecourse
The primary aim of this work is, to 'relate psychological and behavioural parameters of hunger/satiety and food preference to gut hormones, neural activation and energy metabolism by dietary manipulation, across the human…
- Trial name
- F4H (NCT01597024)
- Testing
- Breakfast Study, fMRI Study
- Where
- 3 sites in Greece, Netherlands and 1 more
- Volunteers
- 718 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Endocrine System Diseases
Effect of a Test Meal on Satiation Hormones in Obese and Normal Weight Adolescents
The objective of this study is to examine ghrelin, amylin, glucagon and glucagon-like peptide (GLP)-1 responses to a test meal in lean and obese individuals.
- Trial name
- NCT02020395
- Testing
- test meal (500 kcal)
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Eating Behavior, Overweight
Snacks and Satiety
This study is designed to compare two types of snacks (almonds or a cereal-based snack), eaten between meals, on measures of appetite, including appetitive hormones, self-reported feelings of hunger and fullness, and food intake…
- Conditions
- Eating Behavior, Overweight, Obesity
- Trial name
- NCT03947281
- Testing
- Almond snack, Cereal-based snack
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Incretin Action, Obesity
Oxyntomodulin, Mechanisms of Action in Relation to Appetite, Food Intake, Gastric Emptying and Energy Expenditure.
Tiny molecules (hormones) are released from the bowels and other organs to the bloodstream in response to meals in order to orchestrate the metabolism.
- Trial name
- NCT01232244
- Testing
- GLP-1 infusion, Glucagon infusion, Oxyntomodulin infusion
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Fasting, Intermittent Fasting
Time Restricted Feeding in Male Runners
This is a cross-over intervention study designed to evaluate how four weeks of time restricted feeding (16 hours fasting and 8 hours feeding), compared to four weeks of a more traditional eating pattern (12 hours fasting and 12…
- Conditions
- Fasting, Intermittent Fasting, Athletic Performance, Cardiovascular Risk Factor
- Trial name
- NCT03569852
- Testing
- Time Restrictive Feeding, Traditional Eating Pattern
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Eating Behavior
The Effect of Macronutrients on Satiety and Gut Hormone Responses
This study is part of a research theme aiming at elucidating the physiological mechanisms of action of weight loss after gastric bypass surgery.
- Trial name
- Microcapsule (NCT03466047)
- Testing
- Protein stomach, Protein distal small intestine, CHO stomach
- Where
- Ireland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Appetite and General Nutritional Disorders
The Effects of Whey, Rice and Potato pRotein isOlates on appeTite rEgulatIoN in Healthy Men
INTRODUCTION: Global protein consumption has been increasing for decades due to changes in socio-economic demographics and consumer trends towards higher protein intake, which may be related to their health benefits in…
- Trial name
- PROTEIN (NCT04876495)
- Testing
- Whey protein isolate, Potato protein isolate, Rice protein isolate
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Westminster
Appetite and General Nutritional Disorders
Advanced Protein-based Program for Effective Treatment of Appetite Regulation and Obesity
INTRODUCTION: Obesity is a global epidemic, with over 2.5 billion adults being classified as overweight and 890 million of these classified as obese.
- Trial name
- APPETITE (NCT07104461)
- Testing
- Oat porridge, Whey protein isolate, Potato protein isolate
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Westminster
Energy Intake, Gastrointestinal Hormones
Effects of Oral Pre-loads on Subsequent Energy Intake
The aim of this project is to investigate the effect of erythritol (given as pre-load), compared to sucrose, sucralose, and water on energy intake during a subsequent ad libitum test meal in healthy participants.
- Conditions
- Energy Intake, Gastrointestinal Hormones, Glycemic Control, Appetite
- Trial name
- NCT04713137
- Testing
- Erythritol, Sucrose, Sucralose
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity, Diabetes
The Effects of Carbohydrate Source on Food Intake, Blood Glucose and Gut Hormone Response in Healthy Children
This study will compare the effects of commonly consumed carbohydrate sources such as potatoes, pasta and rice along with a fixed portion of meat on blood glucose, satiety and insulin levels among healthy body weight children.
- Trial name
- NCT02499107
- Testing
- Rice treatment, Pasta treatment, Boiled and mashed potato treatment
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Effects of Lipids on Gastric Emptying, Effects of Lipids on Satiety Hormones
Effects of Lipids on Gastric Emptying, Satiety Hormones, and Appetite in Severe Overweight
In lean subjects, free fatty acid (FFA) promotes gut hormone release, delays gastric emptying, and reduces appetite and energy intake more than an isocaloric load of triglyceride (TG).
- Conditions
- Effects of Lipids on Gastric Emptying, Effects of Lipids on Satiety Hormones, Effects of Lipids on Appetite
- Trial name
- NCT01681459
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Satiety
Satiety Response After Mixed Fiber Doses
People who eat more dietary fiber have a lower body weight than people who eat less fiber. Potential mechanisms include greater feelings of satiety, reductions in food intake, changes in blood glucose, insulin, or gut hormones.
- Trial name
- NCT00889993
- Testing
- Mixed Fiber Supplement
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
The Focus of the Study is Healthy Volunteers
Appetite Regulation by a Breakfast Soft Bread
The aim of this study is to evaluate the appetite rating of a soft bread with a high content of fibre and protein (Puravita Breakfast®) as well as its capacity to modulate postprandial levels of glucose, insulin and…
- Trial name
- NCT02090049
- Testing
- Puravita Breakfast, Control
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Puratos
Childhood Obesity
Brain Activation and Satiety in Children: Functional Magnetic Resonance Imaging
BASIC fMRI is a prospective single center intervention trial using fMRI imaging in 9-11 year old obese male and females pre and post family-based behavioral treatment of 24 weeks duration to determine the relationship between…
- Trial name
- BASIC-FMRI (NCT02484976)
- Testing
- Family Based Behavioral Treatment
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Body Weight, Appetitive Behavior
High Fat vs High Protein and Appetite Hormones
This study will investigate the effects of high-protein, high-fat snacks, specifically Greek yogurt, and peanuts, on satiety, gut hormones, and insulin secretion in overweight and obese women.
- Conditions
- Body Weight, Appetitive Behavior, Dietary Exposure, Hormone Deficiency
- Trial name
- NCT04518930
- Testing
- Peanuts or plain Greek yogurt
- Where
- Jordan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Al-Balqa Applied University