Clinical trials: sponsored by Central Hospital, Nancy, France
Renal Function
Urinary Creatinine Excretion Time in the Neonatal Period
Newborn's renal function is difficult to assess and its physiology during the first days of life is still incompletely known. Studies suggest that the newborn almost completely reabsorbs creatinine during the first 48 to 72 hours…
- Trial name
- C-Rex (NCT05813730)
- Testing
- urinary creatinine excretion measurement
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Auto Immune Disease
Does Borrelia Burgdorferi Increases the Risk of Auto-immune Disease ?
Lyme borreliosis (LB) is an infectious disease that may be followed by a post-infectious syndrome known as PTLDS: Post-Treatment Lyme Disease Syndrome.
- Trial name
- DOBI (NCT07837232)
- Where
- France
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Exercise, Cardiac Function
Acute Cardiac Effects of Ultra-Trail Running
This prospective observational study aims to investigate the acute cardiovascular effects of ultra-endurance running using comprehensive echocardiographic assessment combined with biological analyses.
- Conditions
- Exercise, Cardiac Function, Echocardiography
- Trial name
- ULTRA-ECHO (NCT07753694)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Crohn Disease, Functional Gastrointestinal Disorders
Gastro-intestinal Biopotential Recorder by Means of Surface ELEctrodes
The goal of this clinical trial is to compare the gastro-intestinal biopotentials recorded with a homemade device using surface electrodes placed on the abdomen in healthy volunteers, Crohn's disease patients without fibrosis…
- Conditions
- Crohn Disease, Functional Gastrointestinal Disorders, Healthy
- Trial name
- GRELE (NCT06197334)
- Testing
- Gastro-intestinal biopotentials recording
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Crohn Disease, Spondyloarthritis
Identification of Fecal Microbiota Biomarkers of Spondyloarthritis in Patients Suffering From Crohn's Disease.
The MICROSPA project aims to compare gut microbiota, serum cytokines, and PBMC of patients suffering from Crohn's disease (CD) associated or not to spondylarthritis (SpA).
- Trial name
- MICROSPA (NCT03983473)
- Testing
- Microbiota Sequencing
- Where
- 2 sites in France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Healthy, Temporomandibular Joint Disorders
ChAracterization of Normal and Pathological moRphological Variations of the TEMporomandibular Joint by Real-time magnetIc reSonance Imaging
The Real Time MRI Rapid Flash sequence is particularly interesting for the study of moving organs and joints. This sequence will make it possible to characterize normal and pathological temporomandibular joint movements by MRI.
- Trial name
- ARTEMIS (NCT06070558)
- Testing
- MRI with Real Time MRI Rapid Flash sequence
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Healthy, Pathology
Evaluation of Methodological and Technical DEvelopmeNts to Improve the Quality and Comfort of Magnetic Resonance Imaging Exam on Voluntary Subjects
The EDEN study will make it possible to evaluate one or more development phases (from design to validation through optimization) of a method or a technique on voluntary subjects, in normal or pathological condition.
- Trial name
- EDEN (NCT05218460)
- Testing
- MRI examination
- Where
- France
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Healthy
Cybersickness imAgiNg Olfactory Evocation
The aim of this study is to, using fMRI, compare brain activations during olfactory imagery induced by different visual supports (words, pictures, colors and colored arrangements) in healthy subjects.
- Trial name
- CANOE (NCT05308433)
- Testing
- Functional MRI, Virtual Reality: control, Virtual Reality: experimental
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Healthy Subjects
Imaging of Electrical Properties by MRI: Investigation of Age-Related Changes
The goal of this study is to build a database of personalized EP (Electrical Properties) maps (accounting for age, anatomical location, and tissue complexity), obtained via MRI, to improve electromagnetic safety assessments…
- Trial name
- ELECTRA (NCT07415759)
- Testing
- Magnetic Resonance Imaging (MRI) examination
- Where
- 2 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Alzheimer s Disease, Spatial Orientation
Subjective Assessment of Spatial Orientation Abilities in Alzheimer's Disease
Difficulty orienting oneself and finding one's way around the environment, also known as "topographical disorientation" (TD) or "spatial disorientation" (SD), is a common and often early symptom of Alzheimer's disease (AD) that…
- Trial name
- ESCAPE-AD (NCT07616063)
- Testing
- Questionnaire d'Orientation Spatiale (QOS)
- Where
- France
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Maxillary Transversal Deficiency
Correlation Between Nasal Septal Deviation and Transverse Maxillary Deficiency on CT Scans
The maxillary bones and the nasal septum are interconnected structures. The nasal septum acts as a growth center that facilitates normal maxillofacial growth and development.
- Trial name
- NCT07579091
- Where
- France
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Maturation of the Midpalatal Suture and Maxillary Third Molar Mineralization in Healthy Individuals
Correlation Between the Midpalatal Suture Maturity and the Maxillary Third Molar Mineralization: a CBCT Study
Assessing the maturation of the mid-palatal suture is an essential criterion for orthodontic decision-making. However, from a CBCT according to Angelieri's classification , it remains difficult for the practitioner's untrained…
- Trial name
- NCT07181707
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Peripheral Venous Access
Development and Evaluation of an Algorithm for Vascular Access Management
Two billion catheters are placed annually worldwide. Of all the people requiring vascular access, nearly a quarter have Difficult Intravenous access (DIVA), a source of multiple punctures.
- Trial name
- ALCOV (NCT05935228)
- Testing
- Implementation of the A-DIVA Scale, Implementation of the algorithm composed of the A-DIVA Scale and the new decision-making tree (the A-DIVA Tool) in the centers
- Where
- France
- Volunteers
- 794 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Community Dentistry, Emergencies
Dental Emergencies Among Patients of the Health Care Access Facility at the University Hospital of Nancy
The dental Health Care Access Facility at the University Hospital of Nancy opened in January 2023. The patients ot the dental Health Care Access Facility consulting the dental department have largely been treated as dental…
- Trial name
- urgPASSdent (NCT06507540)
- Testing
- No intervention (observational study)
- Where
- France
- Volunteers
- 611 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Healthy Subjects
Methodological Developments for Magnetic Resonance Imaging (MRI)
The purpose of this study is to optimize clinical MR protocols and to validate MR acquisition parameters.
- Trial name
- METHODO (NCT02887053)
- Testing
- MRI
- Where
- France
- Volunteers
- 1,807 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Healthy Subjects, Patient Performing an MRI Examination
Optimization of the Acquisition Sequence to Improve the Quality and Comfort of Magnetic Resonance Imaging Exam
The purpose of this study is to evaluate the optimization of MRI acquisition sequences.
- Trial name
- AIMANT (NCT04645628)
- Testing
- MRI examination
- Where
- France
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
End Stage Renal Disease
Impact on Quality of Life of Symptoms Routine E-monitoring Among Dialysis Patients.
In France, end-stage renal disease (ESRD) affects almost 170 people per million inhabitants every year, and 92,500 people are treated by dialysis or kidney transplantation (0.14% of the French population).
- Trial name
- F-SWIFT (NCT06257134)
- Testing
- No systematic monitoring of symptoms, Systematic monitoring of symptoms
- Where
- 3 sites in France
- Volunteers
- 2,293 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Phenylketonuria (PKU)
The Psychosocial Functioning of Adults With Phenylketonuria.
Current recommendations are to maintain Phe levels < 360 µmol/L throughout life (US consensus) or < 600 µmol/L from the age of 12 (European consensus).
- Trial name
- CoMet-PCU (NCT07406009)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Down Syndrome (Trisomy 21), Neuropsychology
Neuropsychological Evaluation in Intellectual Disability (ENDI)
The goal of this observational study is to evaluate the acceptability ofpatients with trisomy 21 (T21) to perform the full battery of ENDI neurospychological tests and each of the subsets.
- Conditions
- Down Syndrome (Trisomy 21), Neuropsychology, Cognitive Aging, Alzheimer Disease
- Trial name
- ENDI (NCT07047963)
- Testing
- ENDI (Neuropsychological Evaluation in Intellectual Disability)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Epilepsy, Temporal Lobe, Cognitive Decline
Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients
Anterior temporal epilepsy is the most frequent form of focal epilepsy (more than 50% of focal epilepsies). The epilepsy is drug-resistant when epileptic seizures persist despite antiepileptic treatment (25% of cases).
- Trial name
- CARTA (NCT05339438)
- Testing
- functional MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France