Clinical trials: Misinformation
COVID-19, Vaccination Hesitancy
An Online Game to Help Canadian Adults Identify COVID-19 Vaccine Misinformation With One-Month Follow-Up
COVID-19 vaccine misinformation contributed to vaccine hesitancy and preventable illness. This study tested whether a brief online game helps Canadian adults identify COVID-19 vaccine misinformation, and whether effects last one…
- Conditions
- COVID-19, Vaccination Hesitancy, Health Misinformation, Communication
- Trial name
- NCT07758296
- Testing
- Gamified misinformation refutation quiz, Refutational text blog post (active control)
- Where
- United States
- Volunteers
- 4,071 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Vaccination Hesitancy, Human Papillomavirus Vaccination
Testing the Persuasiveness of Pro-inoculation Arguments
The investigators will recruit a national sample of parents of 7-10-year-olds to complete an argument strength ranking for either a simple forwarding message or between 3 and 6 randomly selected arguments from an overall set of…
- Conditions
- Vaccination Hesitancy, Human Papillomavirus Vaccination, Vaccine Refusal
- Trial name
- NCT05804825
- Testing
- Argument inoculation messages, Simple forewarning message
- Where
- United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy
Building Cognitive Resilience to Vaccine Misinformation Using AI: Evidence From a Randomised Trial
This study aims to understand how parents and caregivers in the United Kingdom engage with information about childhood vaccination (routine vaccines for children and adolescents, excluding tetanus or international travel-related…
- Trial name
- NCT07488962
- Testing
- AI-driven chatbot, Social media infographic
- Where
- United Kingdom
- Volunteers
- 1,008 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Coronavirus, Trust
Migrant Workers' Responses to the COVID-19 Pandemic
Rumors circulate widely during public health crises and have deleterious consequences. In this study, we seek to document the base rates of migrant workers' rumor exposure and identify predictors of rumor hearing, sharing and…
- Conditions
- Coronavirus, Trust, Misinformation
- Trial name
- NCT04718519
- Where
- Singapore
- Volunteers
- 1,011 people, healthy volunteers welcome
- Sponsor
- Yale-NUS College
Vaccine Hesitancy, Vaccine Acceptance
Development and Evaluation of a Digital Educational Intervention to Improve Vaccine Confidence and Communication Among Registered Nurses: Protocol for a Randomized Controlled Trial (VaxNurse-RCT).
Nurses play an important role in providing vaccine information and supporting informed vaccination decisions. This study will evaluate a digital educational intervention designed for registered nurses in Quebec.
- Trial name
- VaxNurse-RCT (NCT07859579)
- Testing
- Digital educational intervention
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universite du Quebec en Outaouais
HPV Vaccine
Impact of a Mock-up Fact-checking Extension on HPV Vaccine Misinformation: A Survey Experiment
The primary objective of this survey experiment study is to measure the impact of a mock-up Chinese fact-checking extension on the ability to dispel HPV and HPV vaccine-related misinformation among parents of middle school girls…
- Trial name
- NCT06405048
- Testing
- Mobile Weibo post screenshot with mock-up Chinese fact-checking extension
- Where
- 2 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Fudan University
Misinformation, HIV Vaccine
Protecting Against HIV Vaccine Misinformation With Adolescent Girls and Young Women in South Africa
Adolescent girls and young women (AGYW) between the ages of 15-29 years continue to bear the brunt of Human Immunodeficiency Virus (HIV) infections in South Africa despite progress recorded in prevention and treatment programmes.
- Trial name
- PROTECT (NCT06700447)
- Testing
- Enhanced inoculation message, Nutrition information
- Where
- South Africa
- Volunteers
- 2,163 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HPV, HPV Vaccine
Digital Interventions to Increase HPV Vaccination Intentions Among Nigerian Caregivers
This study evaluates whether different types of digital health communication can increase parents' intention to vaccinate their daughters against human papillomavirus (HPV) in Nigeria.
- Trial name
- NCT07498075
- Testing
- Chatbot counseling, Misinformation-resistance pre-bunking inoculation, Short edutainment
- Where
- Nigeria
- Volunteers
- 3,340 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy
AI Chatbot for HPV Vaccine Literacy Among Caregivers in Japan
The goal of this study is to learn if an innovative digital artificial intelligence (AI)-based communication tool works to enhance health literacy among Japanese caregivers regarding Human Papillomavirus (HPV) vaccination.
- Trial name
- NCT06702423
- Testing
- AI-based chatbot, Leaflet
- Where
- United Kingdom
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Misinformation
Vaccine Confidence and Infodemic in Southeast Asia's Nusantara Sociocultural Sphere
The goal of this clinical trial is to understand how well a culturally-specific "prebunking" video can improve vaccine information literacy and vaccine confidence among individuals in the Nusantara sociocultural sphere.
- Trial name
- NCT06947187
- Testing
- Pre-bunking video, Video on safe disposal of medication
- Where
- United States
- Volunteers
- 472 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Covid19
WhatsApp in India During the COVID-19 Pandemic
Digital misinformation has been flagged as a major risk of the 21st century, with an estimated cost of $78 billion to the global economy each year.
- Trial name
- NCT04918849
- Where
- Singapore
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Yale-NUS College
Coronavirus, Depression
Social Media and COVID-19
In this protocol, we seek to examine the role of popular messaging platform WhatsApp in information spread during a crisis. As there have been few global crises in the last decade (coinciding with the rise of social media), the…
- Conditions
- Coronavirus, Depression, Anxiety, Stress
- Trial name
- NCT04367363
- Testing
- Social media & news consumption
- Where
- Singapore
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Jean Liu
Pregnancy
Social Media Withdrawal in Pregnancy: Effects on Maternal Mental Health and Misinformation
The goal of this clinical trial is to learn if restricting social media use with a hardware device can improve mental health and well-being during pregnancy.
- Trial name
- SWIPE LEFT (NCT07812506)
- Testing
- Brick device
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy
Building Cognitive Resilience to Vaccine Misinformation Using AI in Europe
This multi-country trial evaluates an AI chatbot designed to counter cognitive biases and inoculate parents against vaccine misinformation, embedded within a large survey across five European countries (n=5,000).
- Trial name
- NCT07551986
- Testing
- AI-driven chatbot, Social media infographic
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
COVID-19, Vaccine Hesitancy
Online Games to Help Canadian and U.S. Adults Identify COVID-19 and Vaccine Misinformation: Three Sequential Randomized Studies
COVID-19 misinformation contributed to vaccine hesitancy and preventable illness. This record covers three sequential randomized studies (conducted in Canada and the United States, November-December 2020) testing whether a brief…
- Conditions
- COVID-19, Vaccine Hesitancy, Health Misinformation, Communication
- Trial name
- NCT07758309
- Testing
- Gamified misinformation refutation quiz, Refutational text (active control)
- Where
- United States
- Volunteers
- 3,637 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
COVID-19
Can Doctors Reduce COVID-19 Misinformation and Increase Vaccine Uptake in Ghana? A Cluster-randomised Controlled Trial
Whilst Ghana was one of the first countries to start vaccinating its population against COVID-19, less than 30% of the population was fully vaccinated at the end of 2022.
- Trial name
- NCT06191211
- Testing
- Motivational Interviewing, AIMS, Facility engagement
- Where
- Ghana
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- London School of Economics and Political Science
Misinformation, Lenacapavir
Protecting Against Lenacapavir Misinformation With Young Women in Gauteng, South Africa ( PROTECT-L)
Adolescent girls and young women (AGYW) in South Africa remain disproportionately affected by HIV, with prevalence among 15-24-year-olds at 9.4% in 2024 despite expanded access to condoms, HIV testing, and oral PrEP.
- Trial name
- PROTECT-L (NCT07518914)
- Testing
- Diabetes information, Enhanced inoculation message
- Where
- South Africa
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cancer
Social Media Posts About Cancer: Five Timepoints
The main purpose of this trial was to evaluate the impact of user interface designs on intervening with cancer misinformation on social media.
- Trial name
- NCT07588607
- Testing
- Social cue prompt and policy, Standard prompts
- Where
- United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
COVID19 Behavioral Prophylaxis
Brief Informational Intervention for COVID-19 Misinformation Prophylaxis
As the coronavirus disease 2019 (COVID-19) pandemic has continued to affect life in the United States, the important role of non-pharmaceutical preventive behaviors (such as wearing a face mask) in reducing harm has become clear.
- Trial name
- NCT04557241
- Testing
- Brief informational infographic
- Where
- United States
- Volunteers
- 1,017 people, healthy volunteers welcome
- Sponsor
- Indiana University
Vaccine Hesitancy, Health Education
Effect of Primary Care Education on Parents' Health-Related Perceptions and Attitudes
This study aims to evaluate the effect of a structured education program delivered in primary health care settings on parents of children aged 0-2 years.
- Conditions
- Vaccine Hesitancy, Health Education, Digital Health Literacy, Eco-anxiety
- Trial name
- NCT07381088
- Testing
- Structured Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University